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Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches

Award Number: R01CA175397
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2013
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches - PROJECT SUMMARY Metastatic progression of the primary tumor accounts for the majority of cancer deaths. While the initial steps of the metastatic cascade are rather well defined, identification of targets to block this process remains a major clinical challenge. Previous studies have elegantly investigated the mechanistic contribution of tumor cell intrinsic properties that promote metastasis in bladder urothelial carcinomas. However, the functional significance of the tumor microenvironment and its contribution to this complicated process is not well characterized, and therefore, warrants investigation. The long-term goal of this renewal application is to continue explore how collagens—a major extracellular matrix component of the microenvironment—act as a ligand to mediate crosstalk with their receptor on tumor cells to facilitate the metastatic cascade. We will investigate the downstream regulatory mechanisms of collagen receptor signaling in both the primary tumor and metastatic sites, and to exploit these regulatory processes as a revolutionizing approach to target metastases. Such innovative approaches to perturb collagen-cancer crosstalk—not only at the primary tumor but also at the metastatic niche—will move the field forward by providing a new conception in metastatic disease management, and likely extend beyond bladder carcinomas to other cancer types.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $385,560 )
2025	2025	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	004	11	5/22/2025	NON-COMPETING CONTINUATION	$385,560
2025	2023	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	003	9	1/15/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$325,307
2025	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	8	1/15/2025	SUPPLEMENT FOR EXPANSION	-$1
2025	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Cancer Biology Research	001	8	1/15/2025	NON-COMPETING CONTINUATION	-$1
2025	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Cancer Biology Research	000	7	1/15/2025	NON-COMPETING CONTINUATION	-$325,305
														Subtotal = $385,560

Issue Date FY: 2024 ( Subtotal = $737,468 )
2024	2024	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	001	10	5/21/2024	NON-COMPETING CONTINUATION	$373,783
2024	2024	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	10	5/22/2024	SUPPLEMENT FOR EXPANSION	$363,685
2024	2023	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	9	12/5/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $737,468

Issue Date FY: 2023 ( Subtotal = $783,790 )
2023	2023	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	002	9	9/7/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$400,962
2023	2023	METHODIST HOSPITAL, THE	6670 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	9	9/19/2023	SUPPLEMENT FOR EXPANSION	$382,828
2023	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Cancer Biology Research	000	8	9/7/2023	NON-COMPETING CONTINUATION	$0
2023	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	8	9/7/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $783,790

Issue Date FY: 2022 ( Subtotal = $2 )
2022	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	8	8/17/2022	SUPPLEMENT FOR EXPANSION	$1
2022	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Cancer Biology Research	000	8	8/4/2022	NON-COMPETING CONTINUATION	$1
														Subtotal = $2

Issue Date FY: 2021 ( Subtotal = $770,799 )
2021	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	7	4/22/2021	SUPPLEMENT FOR EXPANSION	$390,397
2021	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cancer Biology Research	000	7	4/7/2021	NON-COMPETING CONTINUATION	$380,402
														Subtotal = $770,799

Issue Date FY: 2020 ( Subtotal = $392,166 )
2020	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cancer Biology Research	001	6	5/14/2020	COMPETING CONTINUATION	$399,013
2020	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	5	3/2/2020	SUPPLEMENT FOR EXPANSION	-$6,847
														Subtotal = $392,166

Issue Date FY: 2018 ( Subtotal = $110,950 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	5	9/5/2018	SUPPLEMENT FOR EXPANSION	$110,950
														Subtotal = $110,950

Issue Date FY: 2017 ( Subtotal = $324,738 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	002	5	8/1/2017	NON-COMPETING CONTINUATION	$324,738
2017	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	001	4	2/6/2017	EXTENSION WITH OR WITHOUT FUNDS	$603
2017	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	3	2/6/2017	NON-COMPETING CONTINUATION	-$603
														Subtotal = $324,738

Issue Date FY: 2016 ( Subtotal = $324,738 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	4	8/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$324,738
														Subtotal = $324,738

Issue Date FY: 2015 ( Subtotal = $324,738 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	3	7/24/2015	NON-COMPETING CONTINUATION	$324,738
														Subtotal = $324,738

Issue Date FY: 2014 ( Subtotal = $314,995 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	2	7/31/2014	NON-COMPETING CONTINUATION	$314,995
														Subtotal = $314,995

Issue Date FY: 2013 ( Subtotal = $324,738 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	1	9/26/2013	NEW	$324,738
														Subtotal = $324,738

Grand Total All Awards = $4,794,682

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Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches

Award Number: R01CA175397

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2013

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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