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Detecting and Monitoring Implant Infection Using X-ray Excited Luminescence Chemical Imaging (XELCI)

Award Number: R01AR070305
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Approximately half of the two million infections acquired at hospitals in the US are associated with implanted medical devices. Bacterial colonization of implanted medical device surfaces is a major cause of device failure and usually requires device removal coupled with long term antibiotic treatment. Risks of morbidity/mortality from surgery and prolonged hospitalization make early detection critical. However, detection is challenging at early stages prior to development of systemic symptoms of infection when bacteria localized to inaccessible regions of the implant. We will develop a novel medical imaging technique, X-ray excited luminescent chemical imaging (XELCI) to non-invasively detect and monitor bacterial biofilms on modified implant surfaces. Our long term goal is to develop a sensor to detect and monitor in vivo infection. The approach is innovative because no other imaging technique provides surface-specific chemical information at high-resolution through thick tissue. XELCI is a type of scanning optical microscopy wherein a narrow X-ray beam irradiates a radioluminescent film on the implant surface creating a local luminescent spot with pH -dependent spectra. Although the luminescence scatters and blurs as it passes through the tissue in the “far field,” the spectrum depends upon the local pH at the luminescence source, and image resolution is defined by the X-ray beam width. We will apply the technique to detect acidosis beneath biofilms in order to detect and monitor infection. Our two specific aims are to 1) Refine and validate XELCI sensors in vitro and ex vivo; 2) Use XELCI to Assess pH Changes during Healing and Infection in a Rabbit Model. The proposed research is significant because it develops a non-invasive method to detect, monitor, and study biofilms in situ with the ultimate potential for reducing morbidity, mortality and associated cost from implant infections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$1 )
2023	2020	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	11/4/2022	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2020 ( Subtotal = $316,181 )
2020	2020	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	6/15/2020	NON-COMPETING CONTINUATION	$316,181
														Subtotal = $316,181

Issue Date FY: 2019 ( Subtotal = $316,839 )
2019	2019	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/1/2019	NON-COMPETING CONTINUATION	$316,839
														Subtotal = $316,839

Issue Date FY: 2018 ( Subtotal = $317,466 )
2018	2018	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/14/2018	NON-COMPETING CONTINUATION	$317,466
														Subtotal = $317,466

Issue Date FY: 2017 ( Subtotal = $318,063 )
2017	2017	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/10/2017	NON-COMPETING CONTINUATION	$318,063
														Subtotal = $318,063

Issue Date FY: 2016 ( Subtotal = $306,311 )
2016	2016	CLEMSON UNIVERSITY	PO BOX 345355	CLEMSON	SC	29634	PICKENS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/8/2016	NEW	$306,311
														Subtotal = $306,311

Grand Total All Awards = $1,574,859

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Detecting and Monitoring Implant Infection Using X-ray Excited Luminescence Chemical Imaging (XELCI)

Award Number: R01AR070305

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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