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Modeling and simulation tools for optimizing design of network-informed clinical trials of combination HIV prevention interventions

Award Number: R01AI147441
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT The global HIV epidemic continues to evolve, with incidence climbing in some populations, including men who have sex with men (MSM) in the United States, and declining in much of sub-Saharan Africa. While several effective methods to prevent HIV transmission have been found, we still lack understanding of how these varied interventions can best be deployed to curtail the HIV epidemic in a given population and context. The objective of this study is to develop modeling and simulation tools required to optimize the design of randomized controlled trials of network-informed HIV prevention and treatment interventions in specific sub- populations at risk for HIV infection. Agent-based epidemic modeling provides a laboratory in which to test and compare combination prevention programs before implementing costly interventions. The network of contacts has important effects on the spread of disease and the effectiveness of interventions; epidemic models need to account for features of that network. This includes features that can be readily measured from individual self- reports, (e.g., the distribution of the number of sexual partners), but that are subject to reporting biases. It also includes features that are not measurable from individual report, such as a tendency for people with many partners to partner together. The latter features are either not included in epidemic models or included but not informed by data. With this study, our team will develop two related modeling tools: 1) a model that can incorporate many sources of data about a local HIV epidemic to allow us to measure characteristics of the contact network over which the disease spreads, and 2) a new multi-layer network model that simulates trials of HIV prevention that make use of network data in the design of the trial. All tools will be made publicly available through the EpiModel suite of epidemic modeling packages, and demonstrated using data from HIV cohorts in San Diego (the Primary Infection Resource Consortium, or PIRC) and Atlanta (the InvolveMENt and EleMENt cohorts). Strengths of this project include our team's extensive experience with epidemic modeling and statistical methods for networks, and the rich data available from PIRC, InvolveMENt, and EleMENt cohorts. Regarding public health impact, the tools we will develop and make broadly available permit tailoring of interventions for maximum impact on specific sub-populations and thereby address remaining gaps in prevention of HIV in high-risk populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	4	8/21/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$540,947
2023	2021	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Allergy and Infectious Diseases Research	000	3	8/21/2023	NON-COMPETING CONTINUATION	-$540,947
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $610,028 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	4	7/21/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$610,028
2022	2021	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Allergy and Infectious Diseases Research	000	3	1/4/2022	NON-COMPETING CONTINUATION	$0
2022	2021	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Allergy and Infectious Diseases Research	001	3	7/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $610,028

Issue Date FY: 2021 ( Subtotal = $549,516 )
2021	2021	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Allergy and Infectious Diseases Research	000	3	6/23/2021	NON-COMPETING CONTINUATION	$549,516
														Subtotal = $549,516

Issue Date FY: 2020 ( Subtotal = $465,565 )
2020	2020	MONTANA STATE UNIVERSITY, INC	307 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Allergy and Infectious Diseases Research	000	2	6/8/2020	NON-COMPETING CONTINUATION	$465,565
														Subtotal = $465,565

Issue Date FY: 2019 ( Subtotal = $503,925 )
2019	2019	MONTANA STATE UNIVERSITY, INC	307 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Allergy and Infectious Diseases Research	000	1	6/25/2019	NEW	$503,925
														Subtotal = $503,925

Grand Total All Awards = $2,129,034

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Modeling and simulation tools for optimizing design of network-informed clinical trials of combination HIV prevention interventions

Award Number: R01AI147441

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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