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Biological predictors of brain aging trajectories

Award Number: R01AG032289
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2009
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Biological predictors of brain aging trajectories - PROJECT SUMMARY /ABSTRACT There is considerable individual variability in how much and how quickly cognitive abilities change with age. The better we understand the biological mechanisms that influences if and how aging affects brain structure and function, the more able we will be to intervene effectively in a person-specific manner. The overarching goal of this renewal application is to better understand the inflammatory, vascular, neurodegenerative, and lifestyle/behavioral contributions to this clinically important diversity in brain aging trajectories. We propose to continue following our deeply phenotyped cohort of 250 functionally intact older normals with our detailed cognitive, neuroimaging, and biometric characterizing over two additional time points. Our first aim is to define the separate and interactive pathways by which biologic and lifestyle variables influence age-related decline in brain structure and function Our second aim will determine of predictive value of innovative plasma markers of proteins associated with Alzheimer’s and neurodegeneration. Our third aim will incorporate innovative, objective, real-time measures of sleep and physical activity. Accomplishing these aims will have a highly significant impact on the field. Validating plasma biomarkers of pathology and clarifying the complex interplay of factors that influence brain aging trajectories will lead to better prediction and prevention of adverse brain aging and inform person-specific interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,274,515 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	12	9/23/2025	EXTENSION WITH OR WITHOUT FUNDS	$104,055
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	12	4/1/2025	EXTENSION WITH OR WITHOUT FUNDS	$1,170,460
														Subtotal = $1,274,515

Issue Date FY: 2021 ( Subtotal = -$342,049 )
2021	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	10	4/16/2021	NON-COMPETING CONTINUATION	-$342,049
														Subtotal = -$342,049

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	10	9/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $596,608 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	10	6/17/2019	NON-COMPETING CONTINUATION	$596,608
														Subtotal = $596,608

Issue Date FY: 2018 ( Subtotal = $602,587 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	9	5/29/2018	NON-COMPETING CONTINUATION	$602,587
														Subtotal = $602,587

Issue Date FY: 2017 ( Subtotal = $596,607 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	8	6/19/2017	NON-COMPETING CONTINUATION	$596,607
														Subtotal = $596,607

Issue Date FY: 2016 ( Subtotal = $596,608 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	7	5/26/2016	NON-COMPETING CONTINUATION	$596,608
														Subtotal = $596,608

Issue Date FY: 2015 ( Subtotal = $602,587 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	6	8/20/2015	COMPETING CONTINUATION	$602,587
														Subtotal = $602,587

Issue Date FY: 2013 ( Subtotal = $483,693 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	5	5/29/2013	NON-COMPETING CONTINUATION	$483,693
														Subtotal = $483,693

Issue Date FY: 2012 ( Subtotal = $589,022 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	4	5/4/2012	NON-COMPETING CONTINUATION	$544,617
2012	2012	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	3	3/30/2012	SUPPLEMENT FOR EXPANSION	$44,405
														Subtotal = $589,022

Issue Date FY: 2011 ( Subtotal = $423,503 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	3	6/23/2011	NON-COMPETING CONTINUATION	$423,503
														Subtotal = $423,503

Issue Date FY: 2010 ( Subtotal = $482,480 )
2010	2010	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	2	5/19/2010	NON-COMPETING CONTINUATION	$482,480
														Subtotal = $482,480

Issue Date FY: 2009 ( Subtotal = $484,395 )
2009	2009	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	1	6/2/2009	NEW	$484,395
														Subtotal = $484,395

Grand Total All Awards = $6,390,556

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Biological predictors of brain aging trajectories

Award Number: R01AG032289

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2009

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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