Thursday, April 18, 2024 4/18/2024

The Role of Akt in Cell Survival and Cell Growth

Award Number: R01AG016927
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

During the last 20 years, we have been characterizing mice with different Akt isoforms deficiencies for survival, lifespan, and susceptibility to cancer at the cellular and organismal levels. The current renewal application is focused on the systemic effect of Akt isoforms deletion in adult mice. First, the systemic deletion of Akt1 and Akt2 as well as moderate to high doses of pan-Akt inhibitor in adult mice induces intestinal damage, loss of body weight, and eventually mortality. Thus, in the first part of this grant application we will delineate the mechanism of the intestinal damage and will employ approaches to alleviate it. Second, we found a marked discrepancy between the systemic effect and cell autonomous effect of Akt1 or Akt2 deletion on tumor initiation, progression, and metastasis. These results underscore the importance of determining the systemic effect of gene targeting for cancer therapy. We will delineate the mechanisms by which the systemic deletions of Akt1 or Akt2 in adult mice exert their effects on tumor progression and metastasis in mouse models of breast cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $456,744 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	25	3/17/2023	NON-COMPETING CONTINUATION	$456,744
														Subtotal = $456,744

Issue Date FY: 2022 ( Subtotal = $456,744 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	001	24	6/13/2022	NON-COMPETING CONTINUATION	$45,676
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	24	3/10/2022	NON-COMPETING CONTINUATION	$411,068
														Subtotal = $456,744

Issue Date FY: 2021 ( Subtotal = $456,744 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	23	3/17/2021	NON-COMPETING CONTINUATION	$456,744
														Subtotal = $456,744

Issue Date FY: 2020 ( Subtotal = $456,744 )
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	002	22	2/25/2020	NON-COMPETING CONTINUATION	$456,744
2020	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	001	21	2/1/2020	COMPETING CONTINUATION	$641
2020	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	20	2/1/2020	NON-COMPETING CONTINUATION	-$641
														Subtotal = $456,744

Issue Date FY: 2019 ( Subtotal = $426,844 )
2019	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	003	21	8/16/2019	COMPETING CONTINUATION	$29,102
2019	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	002	21	6/10/2019	COMPETING CONTINUATION	-$15,280
2019	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	001	21	3/29/2019	COMPETING CONTINUATION	$413,022
2019	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	20	3/20/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $426,844

Issue Date FY: 2018 ( Subtotal = $455,327 )
2018	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	20	2/6/2018	NON-COMPETING CONTINUATION	$409,794
2018	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	001	20	4/13/2018	NON-COMPETING CONTINUATION	$45,533
														Subtotal = $455,327

Issue Date FY: 2017 ( Subtotal = $455,327 )
2017	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	000	19	1/25/2017	NON-COMPETING CONTINUATION	$409,794
2017	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Aging Research	001	19	6/19/2017	NON-COMPETING CONTINUATION	$45,533
														Subtotal = $455,327

Issue Date FY: 2016 ( Subtotal = $451,912 )
2016	2016	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	18	1/26/2016	NON-COMPETING CONTINUATION	$451,912
														Subtotal = $451,912

Issue Date FY: 2015 ( Subtotal = $436,935 )
2015	2015	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	17	2/24/2015	NON-COMPETING CONTINUATION	$436,935
														Subtotal = $436,935

Issue Date FY: 2014 ( Subtotal = $405,451 )
2014	2014	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	16	1/14/2014	COMPETING CONTINUATION	$405,451
														Subtotal = $405,451

Issue Date FY: 2013 ( Subtotal = $376,738 )
2013	2013	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	15	1/17/2013	NON-COMPETING CONTINUATION	$358,798
2013	2013	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	001	15	5/23/2013	NON-COMPETING CONTINUATION	$17,940
														Subtotal = $376,738

Issue Date FY: 2012 ( Subtotal = $397,687 )
2012	2012	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	14	2/9/2012	NON-COMPETING CONTINUATION	$397,687
														Subtotal = $397,687

Issue Date FY: 2011 ( Subtotal = $397,906 )
2011	2011	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	13	2/25/2011	NON-COMPETING CONTINUATION	$372,244
2011	2011	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	001	13	6/20/2011	NON-COMPETING CONTINUATION	$25,662
														Subtotal = $397,906

Issue Date FY: 2010 ( Subtotal = $407,215 )
2010	2010	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	12	2/11/2010	NON-COMPETING CONTINUATION	$407,215
														Subtotal = $407,215

Issue Date FY: 2009 ( Subtotal = $386,222 )
2009	2009	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Aging Research	000	11	1/13/2009	COMPETING CONTINUATION	$386,222
														Subtotal = $386,222

Issue Date FY: 2007 ( Subtotal = $365,826 )
2007	2007	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Aging Research	000	10	7/25/2007	NON-COMPETING CONTINUATION	$365,826
														Subtotal = $365,826

Issue Date FY: 2006 ( Subtotal = $376,753 )
2006	2006	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Aging Research	000	9	7/27/2006	NON-COMPETING CONTINUATION	$376,753
														Subtotal = $376,753

Issue Date FY: 2005 ( Subtotal = $385,820 )
2005	2005	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Aging Research	000	8	7/28/2005	NON-COMPETING CONTINUATION	$385,820
														Subtotal = $385,820

Issue Date FY: 2004 ( Subtotal = $385,820 )
2004	2004	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Aging Research	000	7	9/1/2004	NON-COMPETING CONTINUATION	$385,820
														Subtotal = $385,820

Issue Date FY: 2003 ( Subtotal = $380,233 )
2003	2003	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Aging Research	000	6	7/15/2003	COMPETING CONTINUATION	$380,233
														Subtotal = $380,233

Grand Total All Awards = $9,453,166

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The Role of Akt in Cell Survival and Cell Growth

Award Number: R01AG016927

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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