Tuesday, April 16, 2024 4/16/2024

Yale Liver Center

Award Number: P30DK034989
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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PROJECT SUMMARY – OVERALL This is a renewal application for support of the Yale University Digestive Disease Research Core Center, a multidisciplinary Center whose research focus is Liver Structure, Function and Disease. Thirty-four independently funded investigators comprise a current digestive disease related-research base of ~$23 million, and all of these individuals actively collaborate with other Liver Center members. There are an additional 52 associate members engaged in liver-related research, 40% of whom also have independent funding. Research programs in the Center are distributed across 17 Departments of the University including Biomedical Engineering; Cell Biology; Cellular and Molecular Physiology; Comparative Medicine; Epidemiology and Public Health; Human Genetics; Immunobiology; Internal Medicine; Microbial Pathogenesis; Molecular Biophysics and Biochemistry; Obstetrics and Gynecology; Pathology; Pediatrics; Pharmacology; Radiology, Surgery, and Urology. The research base focuses on three major basic/translational themes: (1) Hepatic metabolism, (2) Immunobiology and inflammation, and (3) Epithelial biology/pathobiology. The research programs are broad and range from fundamental studies of the biology of liver and related digestive systems to translational studies of immediate clinical relevance. The major areas of liver disease examined within these translational themes include autoimmune diseases, cholestasis, fibrosis/cirrhosis, genetic diseases, infections, liver cancer, and NASH/ASH. The major goals of the Center continue to be: (1) to stimulate multidisciplinary interactions between basic and clinical faculty and departments, (2) to provide an in-depth training environment, (3) to efficiently organize time consuming, often costly techniques and procedures in Core Facilities for use by multiple investigators, (4) to stimulate basic scientists to direct their focus to areas of interest to the Center, (5) to stimulate translational research from bench to bedside, (6) to promote new research and training opportunities with a pilot feasibility program, and (7) to create an intellectual environment within the field by fostering collaborations both within and outside the institution through its enrichment program. To achieve these goals the Center is organized into four Core Facilities including: (1) Administrative Core, (2) Cellular and Molecular Physiology Core, (3) Morphology Core and (4) Clinical/Translational Core. A Pilot Feasibility Program supports one- to two-year small grants for new scientific initiatives. The Enrichment Program consists of research seminars, symposia, visiting professorships, and retreats.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,268,283 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	39	3/26/2024	SUPPLEMENT FOR EXPANSION	$137,655
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	39	3/5/2024	NON-COMPETING CONTINUATION	$1,130,628
														Subtotal = $1,268,283

Issue Date FY: 2023 ( Subtotal = $1,256,253 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	38	3/30/2023	NON-COMPETING CONTINUATION	$1,256,253
														Subtotal = $1,256,253

Issue Date FY: 2022 ( Subtotal = $1,256,253 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	37	3/4/2022	NON-COMPETING CONTINUATION	$1,130,628
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	37	3/30/2022	NON-COMPETING CONTINUATION	$125,625
														Subtotal = $1,256,253

Issue Date FY: 2021 ( Subtotal = $1,306,980 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	36	3/23/2021	COMPETING CONTINUATION	$1
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	36	5/31/2021	SUPPLEMENT FOR EXPANSION	$50,730
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	36	3/18/2021	COMPETING CONTINUATION	$1,256,250
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	36	3/25/2021	COMPETING CONTINUATION	$0
2021	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	35	3/8/2021	NON-COMPETING CONTINUATION	-$1
														Subtotal = $1,306,980

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	35	11/27/2019	NON-COMPETING CONTINUATION	$0
2020	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	35	12/10/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $1,120,132 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	35	8/14/2018	NON-COMPETING CONTINUATION	$1,120,132
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	35	9/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,120,132

Issue Date FY: 2017 ( Subtotal = $1,138,276 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	34	9/4/2017	NON-COMPETING CONTINUATION	$1,138,276
														Subtotal = $1,138,276

Issue Date FY: 2016 ( Subtotal = $1,138,276 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	33	8/25/2016	NON-COMPETING CONTINUATION	$1,138,276
														Subtotal = $1,138,276

Issue Date FY: 2015 ( Subtotal = $1,151,129 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	32	9/3/2015	SUPPLEMENT FOR EXPANSION	$12,853
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	32	9/1/2015	NON-COMPETING CONTINUATION	$1,138,276
														Subtotal = $1,151,129

Issue Date FY: 2014 ( Subtotal = $1,138,276 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	31	8/22/2014	COMPETING CONTINUATION	$1,138,276
2014	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	30	8/19/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,138,276

Issue Date FY: 2013 ( Subtotal = $1,153,979 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	30	9/3/2013	NON-COMPETING CONTINUATION	$1,153,979
														Subtotal = $1,153,979

Issue Date FY: 2012 ( Subtotal = $1,241,250 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	29	9/17/2012	NON-COMPETING CONTINUATION	$20,108
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	29	7/24/2012	NON-COMPETING CONTINUATION	$1,221,142
														Subtotal = $1,241,250

Issue Date FY: 2011 ( Subtotal = $1,221,142 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	7/21/2011	NON-COMPETING CONTINUATION	$1,221,142
														Subtotal = $1,221,142

Issue Date FY: 2010 ( Subtotal = $1,359,095 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	27	8/4/2010	NON-COMPETING CONTINUATION	$1,241,250
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	006	27	9/20/2010	SUPPLEMENT FOR EXPANSION	$68,195
2010	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	26	5/13/2010	COMPETING CONTINUATION	$0
2010	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	26	11/6/2009	COMPETING CONTINUATION	$49,650
2010	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	26	11/6/2009	COMPETING CONTINUATION	$0
2010	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Trans-NIH Recovery Act Research Support	003	25	6/15/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Trans-NIH Recovery Act Research Support	004	25	7/6/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,359,095

Issue Date FY: 2009 ( Subtotal = $1,538,180 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	26	7/30/2009	COMPETING CONTINUATION	$1,191,600
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	26	9/21/2009	COMPETING CONTINUATION	$49,650
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Trans-NIH Recovery Act Research Support	001	25	7/15/2009	SUPPLEMENT FOR EXPANSION	$296,930
2009	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Digestive Diseases and Nutrition Research	000	25	12/9/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,538,180

Grand Total All Awards = $29,228,430

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Yale Liver Center

Award Number: P30DK034989

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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