The California Department of Public Health (CDPH) has conducted cancer prevention and control activities funded by the Centers for Disease Control for more than 35 years. These include high performing, nationally recognized programs, including the California Cancer Registry (CCR), the Every Woman Counts (EWC) program (which administers California?s National Breast and Cervical Cancer Early Detection Program), and the California Comprehensive Cancer Control Program (CCCCP). These programs aim to save lives of Californians by preventing and reducing the devastating effects of cancer across the cancer control continuum through education, early detection, diagnosis, treatment, and integrative preventive services with a special emphasis on the underserved. At its core, the purpose of CCR is to monitor the burden of cancer across the entire state, assist in cancer control program evaluation and guidance, respond to public concerns about cancer, and provide high quality structured data in near real time in support of research, preventive and clinical care, and improving cancer outcomes for all survivors. EWC?s primary mission is to reduce morbidity and mortality due to breast and cervical cancer in underinsured California women through provision of educational and screening services to enhance early detection of these cancers when they are the most treatable. CCCCP?s overarching goals are to provide the infrastructure to ensure coordination of cancer control efforts in California, engagement of all cancer control constituents through the California Dialogue on Cancer, and develop our state?s Cancer Control Plan to guide and evaluate other programs? and stakeholders? activities based on the latest evidence based strategies. The three programs described in this proposal are highly committed to collaboration among themselves as well as with external partners to achieve the ultimate goal of reducing the cancer burden of California and the nation.