Project Summary/Abstract
As the population ages, Latinx communities, families, and healthcare systems will be confronted by the
growing crisis of Alzheimer's disease and related dementias (ADRD). Identifying factors that confer resilience
to ADRD among aging Latinx communities is of critical importance to successfully reduce disparities. Some
studies find that bilinguals are at reduced AD risk compared to monolinguals, but other studies do not find
evidence of a bilingual advantage. Little attention has been given to within-group differences among bilinguals,
such as age of second language (L2) acquisition, proficiency, and frequency of language use, and how these
differences 1) are related to cognitive function in older age, 2) if they buffer the effects of neuropathology on
cognitive decline, and 3) how cognitive decline in AD can influence language use among bilinguals.
Determination of the aspects of bilingualism that confer resilience to AD could lead to novel interventions to
mitigate cognitive aging and ADRD disparities. The overall aim of this proposed research is to determine
whether aspects of bilingualism, including age of acquisition, language use, and proficiency, buffer the effects
of neuroimaging markers of pathology (i.e., AD biomarkers and cerebrovascular disease) on cognition and
cognitive decline within middle- and older-aged Latinx adults. The central hypothesis is that early age of L2
acquisition, greater daily use of both L1 and L2, and greater L2 proficiency will confer cognitive reserve,
independent of confounding sociocultural factors (i.e., education, socioeconomic status, immigration). Aims 1a
and 1b (K99) focus on identifying which aspects of bilingualism are associated with cognition and which
moderate the relationship between imaging markers and cognition. Aims 2a and 2b (R00) proposes to
determine the relationship between bilingualism and imaging markers on cognitive decline and determine
whether change in cognitive status is associated with changes in bilingualism. The proposed study will
harmonize data from Latinx adults currently enrolled in three longitudinal cohorts with available amyloid and
tau PET, MRI, and cognitive assessments: the Offspring study and the Washington Heights-Inwood Columbia
Aging Project at Columbia University, and the University of California-Davis Diversity Aging Cohort. To
accomplish these goals, the applicant will build on his strengths in cultural neuropsychology, health disparities,
and statistical methods by obtaining training during the K99 phase on 1) expanding knowledge of the cognitive
neuroscience and psycholinguistics of bilingualism; 2) modeling neuroimaging data; 3) the operationalization
and measurement of resilience among aging Latinx populations; and 4) enhancing statistical methods focused
on data harmonization, casual inference methods and latent variable modeling. This K99/R00 proposal lays the
foundation for an independent research career focused on mechanisms underlying the protective factors of
bilingualism and biculturalism in cognitive aging in a diverse population.