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Dissecting the extrinsic regulators of cancer dormancy in the local and distant microenvironments

Award Number: K00CA284258
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/11/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2029

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Dissecting the extrinsic regulators of cancer dormancy in the local and distant microenvironments - Metastatic cancers often manifest in the skeleton. The lesions arise from disseminated tumor cells (DTCs) that often persist in a dormant state for months to decades after initial primary tumor treatment. Despite our knowledge that DTCs give rise to incurable bone metastatic cancer, there remains gaps in our understanding as to the cellular changes within the local and distant microenvironments underpinning entry and reawakening from the dormancy program. Insight into those mechanisms could yield new therapeutic approaches that would prevent the metastatic relapse and ultimately death of numerous cancer patients each year. To address this, we have developed novel syngeneic mouse models of cancer dormancy and reawakening across multiple cancer types including breast, prostate, and pancreatic cancer. These syngeneic models allow the investigation of how dormant DTCs within the bone alters the microenvironment around to facilitate or prevent metastatic outbreak in the bone. Moreover, these models allow the investigation of systemic changes (macroenvironment) resulting from dormant DTCs inhabiting the bone marrow. This investigation is of critical importance for prostate and breast cancer patients among others, because cancer cells often metastasize to the bone microenvironment, while patients succumb due to one or multiple metastases such as liver or lung metastases. Taken together we aim to investigate how dormant DTCs alter the microenvironment to prevent or facilitate reawakening of DTCs within the local or distant microenvironments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $95,495 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Research Manpower	001	3	4/17/2026	EXTENSION WITH OR WITHOUT FUNDS	$9,549
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Research Manpower	000	3	2/19/2026	EXTENSION WITH OR WITHOUT FUNDS	$85,946
														Subtotal = $95,495

Grand Total All Awards = $95,495

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Dissecting the extrinsic regulators of cancer dormancy in the local and distant microenvironments

Award Number: K00CA284258

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/11/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2029

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