Project Abstract Summary. Panthers4Life aims to prevent suicidal ideation and behavior (SIB), substance use, and posttraumatic stress disorder (PTSD) among high-risk college students including Black students, first generation college students, international students, LGBT students, and Veteran students. Panthers4Life will use a comprehensive, well-coordinated, and evidence-based approach to enhance the existing infrastructure at Georgia State University (GSU) to achieve this goal. GSU is an urban public research institution in Atlanta and serves more than 54,000 students. On a given year at GSU, it is estimated that there will be 20,196 Black students, 9,858 students that identify as LGBT, 3,000 Veteran students, 13,000 first generation college students, and 3,000 international students. This project has four primary goals: 1) Establish community partnerships in the greater-Atlanta area with behavioral healthcare providers who focus on the prevention/treatment of substance misuse, PTSD, and suicidality among high-risk populations; 2) Increase training with college students, faculty, and staff at GSU to respond effectively to college students with mental and substance use disorders; 3) Administer voluntary mental and substance use disorder screening assessments; and 4) Create and implement a practicum for GSU Clinical Psychology and Counseling Psychology graduate students to provide services to GSU students focused on suicide, substance use, and PTSD. To achieve these goals, we will use the following strategies/interventions: (1) Adapt counseling and wellness websites to link students at GSU with providers who treat mental and substance use disorders in Years 1-3 (estimated to reach n=5000); (2) Disseminated activities, webinars, and newsletters on these website in Years 1-3 (estimated to reach n=500); (3) Conduct a community needs assessment in Year 1 to (a) understand current intentions and barriers to responding effectively to students with mental and substance use disorders and perceived trainings that would be beneficial and (b) cultural factors associated with mental and substance use disorders to integrate into intervention (n=400); (4) Develop and assess an online screening and brief intervention tool to provide evidence-based screening, brief intervention, and referral to treatment to GSU students for SIB, substance use, and PTSD (estimated reach, n=100 during entire project period); (5) Attend student events and conduct screening for SIB, substance use, and PTSD and provide referral to treatment as needed in Years 2-3 (estimated reach n=200); (6) Enhance outreach regarding currently offered services for substance use at GSU Counseling Center in Years 2-3 (estimated reach n=100); and (7) Implement evidence-based groups for GSU students to address suicide (e.g., emotion regulation skills training), substance use (e.g., relapse prevention), and PTSD in Years 2-3 (n=50). We estimate that through the lifetime of Panthers4Life, we will reach 7,650 high-risk students at GSU through these strategies/interventions aimed at preventing SIB, substance use, and PTSD. In sum, Panthers4Life will provide much needed prevention, treatment, outreach, and training focused on SIB, substance use, and PTSD for high-risk college students.