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Harnessing Observational Data through Causal Inference to Reduce Hospital Readmissions for Survivors of Pneumonia with Respiratory Failure

Award Number: F32HL182325
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/26/2025
PERIOD OF PERFORMANCE END DATE: 08/25/2026

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Harnessing Observational Data through Causal Inference to Reduce Hospital Readmissions for Survivors of Pneumonia with Respiratory Failure - PROJECT SUMMARY/ABSTRACT Candidate’s Long-Term Career Goals: By pursuing the training plan outlined in this F32 proposal, Dr. Andrew Davis will learn key skills in clinical epidemiology, causal inference, and informatics while writing a K23 award and ultimately becoming an independent health services researcher investigating evidenced-based interventions to improve outcomes for survivors of pneumonia and respiratory failure. Clinical Problem to be Addressed: Community acquired pneumonia (CAP) with hypoxemia remains a major driver of hospitalizations, readmissions and new post-discharge morbidity. Current CAP guidelines are limited and make no recommendations on best practices to support the safe discharge of patient’s home. Candidate Background: Dr. Davis is a postdoctoral fellow in Pulmonary and Critical Care Medicine at Johns Hopkins University. He received his MD from the University of Pennsylvania (2019) after completing an Intramural Research Training Award fellowship at the NIH (2013-2015). He has coauthored 9 peer-reviewed publications and presented 6 oral and 8 poster presentations at national conferences. His department is strongly committed to his scientific career and has awarded him a 1-year fellowship on a T32 training grant. Career Development Plan: In order to achieve his goals, he proposes to develop expertise in biostatistics, clinical epidemiology, and bioinformatics through completing the research aims outlined in this proposal under the close guidance of his mentorship team, as well as through pursuing formal coursework leading to a Master of Health Science (MHS) degree from the Johns Hopkins Bloomberg School of Public Health. Mentors: His primary mentor is Dr. Theodore J. Iwashyna at the Johns Hopkins School of Medicine, who has supervised 15 K-level or equivalent career development awards of whom 10 have so far transitioned to PI of R- level awards or equivalents. He will be co-mentored in bioinformatics by Dr. Khyzer Aziz, assistant professor of pediatrics and Chief Medical Information Officer at the Johns Hopkins Children’ Center, and in biostatistics by Dr. Akihiko Nishimura, assistant professor of biostatistics at the Bloomberg School of Public Health. Aims: He will use the Johns Hopkins Precision Medicine Analytics Platform (PMAP) comprising observational data from 2.4 million patients and 23 million healthcare encounters in both research aims. First, he will perform a target trial emulation evaluating the effect of scheduling early primary care follow-up at discharge following admission for hypoxemic CAP. Then he will develop the informatics infrastructure needed to investigate optimal discharge diuretic regimens for survivors of CAP with comorbid heart failure in his future K23 award proposal. Deliverables from Aims: His proposed aims will lead to 3-4 publications over 2 years with semiannual presentations at national conferences. This proposal constitutes the foundation for a future K23 application to develop evidence-based guidelines to improve outcomes for survivors of pneumonia and respiratory failure by supporting their safe discharge home following hospital admission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $101,360 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Lung Diseases Research	000	1	8/26/2025	NEW	$101,360
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Lung Diseases Research	001	1	8/26/2025	NEW	$0
														Subtotal = $101,360

Grand Total All Awards = $101,360

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Harnessing Observational Data through Causal Inference to Reduce Hospital Readmissions for Survivors of Pneumonia with Respiratory Failure

Award Number: F32HL182325

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/26/2025

PERIOD OF PERFORMANCE END DATE: 08/25/2026

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