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Designing Ligand Platforms of Titanium Imido Catalysts and Statistically Screening Alkyne Substrates for [2+2+1] Regioselective Pyrrole Synthesis

Award Number: F32GM137547
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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Project Summary/Abstract Substituted pyrroles are pivotal organic building blocks in pharmaceuticals, materials, and natural products, however, these scaffolds are often difficult targets. Recently, a titanium imido complex was found to be effective in catalyzing [2+2+1] synthesis of pyrroles using simple alkyne and diazene starting materials. This three-component oxidative coupling offers a new methodology for catalytic pyrrole synthesis and has the potential to be a valuable synthetic tool for organic synthesis of pharmaceuticals and natural products containing a pyrrole core. This research proposal seeks to expand this work by improving regioselective synthesis of pyrroles via catalyst control and to improve rates of reaction by tuning electronic properties of ancillary ligands by modulating arylchalcogenides. In addition, dinitrogen will also be utilized as a new nitrogen source for pyrrole synthesis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$39,492 )
2023	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	2	5/15/2023	NON-COMPETING CONTINUATION	-$14,877
2023	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	2	10/20/2022	NON-COMPETING CONTINUATION	-$24,615
														Subtotal = -$39,492

Issue Date FY: 2022 ( Subtotal = $67,582 )
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	2	12/9/2021	NON-COMPETING CONTINUATION	$66,390
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	2	5/11/2022	NON-COMPETING CONTINUATION	$1,191
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	002	2	5/25/2022	NON-COMPETING CONTINUATION	$1
														Subtotal = $67,582

Issue Date FY: 2021 ( Subtotal = $65,994 )
2021	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	000	1	12/17/2020	NEW	$64,926
2021	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	001	1	12/17/2020	NEW	$0
2021	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Biomedical Research and Research Training	002	1	2/4/2021	NEW	$1,068
														Subtotal = $65,994

Grand Total All Awards = $94,084

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Designing Ligand Platforms of Titanium Imido Catalysts and Statistically Screening Alkyne Substrates for [2+2+1] Regioselective Pyrrole Synthesis

Award Number: F32GM137547

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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