Monday, February 6, 2023
2/6/2023
PROJECT ABSTRACT The goal of the proposed project is to provide Ms. Brianna Kiefer with training opportunities at Purdue and Columbia University from Drs. Jessica Huber, Michelle Troche, and Kristine Marceau – experts in speech science, respiration, cough physiology, and multilevel modeling. To achieve this goal, Ms. Kiefer will conduct a study of expiratory muscle strength training (EMST) in people with Amyotrophic Lateral Sclerosis (ALS). Progressive muscular atrophy is a detrimental consequence of motor neuronal death associated with ALS. Atrophy of the respiratory musculature is particularly harmful since speech and cough production require ample and coordinated respiratory support. Due to respiratory musculature atrophy, people with ALS are unable to generate sufficient subglottal pressures to support speech. People with ALS are also unable to generate strong expiratory forces to effectively expel foreign materials from the airway when they cough. Consequently, people with ALS often rely on alternative communication devices and alternative methods of nutrition. Losing the abilities to speak and eat independently significantly reduces quality of life for people with ALS. Recent investigations have found that implementing moderate intensity strength training paradigms in the early stages of ALS is safe and effective. EMST is a commonly used paradigm that strengthens the respiratory musculature to improve speech and cough production. While EMST has a large body of literature to support its use for people with other neurodegenerative diseases, only one study has examined the effectiveness of EMST for people with ALS. The proposed project aims to build upon Plowman and colleagues (2016) findings to address three broad aims. Specific aim 1 will define how the underlying respiratory support patterns mediating speech and cough production are altered by ALS. We suspect that individuals with ALS will utilize less efficient and effective respiratory support patterns during speech and cough production relative to age- and sex-matched controls. Specific Aim 2 will determine how moderate intensity EMST modifies the effectiveness and efficiency of speech and cough production. In a multiple baseline, delayed-treatment design, people with ALS will undergo a six-week moderate intensity EMST protocol. We suspect that EMST will improve the effectiveness and efficiency of speech and cough production. And finally, Specific Aim 3 will identify how EMST affects the psychosocial states of people with ALS. We suspect that improved speech and cough production will positively impact the psychosocial states of people with ALS. Together, results from the proposed study will provide much needed information to guide clinical practice in the treatment of dysarthria and dystussia associated with ALS. Through conducting this study and engaging with her mentors in a variety of activities, Ms. Kiefer will greatly expand her research skills. Specifically, she will gain experience with ALS, reflexive cough production, respiratory function, multilevel models, and clinical trial management.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
