University of Kansas Medical Center Research Institute, Inc., MSN 1039, 3901 Rainbow Blvd, Kansas City, KS 66103-2937 KUCC Director: Roy Jensen, MD, 913-588-2568, rjensen@kumc.edu $10,000,000 The University of Kansas Cancer Center (KUCC) is a matrix consortium cancer center with three research programs: 1) Cancer Biology, 2) Cancer Prevention and Control, and 3) Drug Discovery, Delivery and Experimental Therapeutics. In 2020, 171 members of KUCC accounted for $9.7M of NCI funding and a total of $57M in overall cancer-related funding, an increase of $8M since the last CCSG submission. Supported by an experienced, nationally recognized leadership team, Roy A. Jensen, MD, has led KUCC on a strong upward trajectory that has been catalyzed by over $467M philanthropic support since 2004. The research of the KUCC faculty members is supported in part by several core facilities and shared resources on the KUMC campus. These shared facilities are the backbone for expanding innovations in cancer research over the next decade, and critical for the advancement of cancer research as a whole. This proposal requests cancer research equipment for the following areas: Proteomics, Biospecimen Repository, Imaging, Flow Cytometry, Bioinformatics, Microscopic Imaging, and Essential Basic Science equipment. These new instruments will help provide cutting edge technology and the optimal environment to focus the power of precision medicine, basic science inquiry, drug discovery and development, and behavioral interventions to decrease cancer incidence, morbidity, and mortality. These enhancements will increase our competitive capabilities and also advance team science by fostering innovative partnerships and collaborations.