HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please email our help desk at Readiness Help
Prime Recipient Report
Award Detail for: SLO2 K+ CHANNELS: A MAJOR SYSTEM CONTROLLING EXCITABILITY IN THE BRAINRecipient Name:WASHINGTON UNIVERSITY
DUNS Number: 068552207
CAMPUS BOX 1034
SAINT LOUIS, MO 63112
Reporting Information
Award Type*: Grant
Award Number*: 1R01NS061871-01A2
Final Report*: Recipient responsible for this data
Award Recipient Information
Recipient DUNS Number*: 068552207
Recipient Account Number: Recipient responsible for this data
Recipient Congressional District*: 1
Award Information
Funding Agency Code*: 7529
Awarding Agency Code*:7529
Award Date*: 09-14-2009
Amount of Award*: $ 404,896
Program Source (TAS)*: 750901
CFDA Number*: 93.701
Sub Account Number for Program Source (TAS)*: Recipient responsible for this data
Total Number of Sub Awards to Individuals*: Recipient responsible for this data
Total Amount of Sub Awards to Individuals*: Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award*: Recipient responsible for this data
Total Amount of Payments to Vendors less than $25,000/award*: Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award*: Recipient responsible for this data
Total Amount of Sub Awards less than $25,000/award*: Recipient responsible for this data
Award Description* We believe that our most recent work studying the electrical properties of neurons of the brain represents a breakthrough in understanding how potassium channels control the excitability of neuronal electrical activity, and may have a significant impact on both basic and clinical neuroscience. We have recently shown that one of the largest components of delayed outward potassium conductance in many neuronal types, during normal physiology has gone unnoticed and is the product of Na+-activated SLO2 (Slack) channels. Previous studies of potassium conductances in mammalian neurons may have overlooked this large component of outward current because the Na+ channel blocker TTX is typically used in studies of mammalian K+ channels and TTX also removes SLO2 currrents as a secondary consequence of its block of Na+ entry. Since most prior studies of the electrical properties of CNS neurons have overlooked the large SLO2 component, we propose to show its contribution to the electrical properties of neurons in several brain regions where it is prominently expressed. This will allow a more thorough understanding of the currents that determine neuronal electrical activity and may reveal SLO2 channels as useful pharmacological targets for the control of epilepsy and other seizure disorders. Because SLO2 channels are prominently expressed in the striatum they may also be a useful target in the treatment of Parkinson's Disease and in the treatment of depressive illness. In addition to showing the contribution of SLO2 channels to neuronal electrical excitability, we will also reveal more about the mechanism of SLO2 K+ current activation. We previously discovered that the SLO2 K+ current is activated by Na+ entry through a persistent inward sodium conductance. Thus, we will determine the genetic identity of one or more sodium channels that carry such a persistent sodium current capable of activating SLO2 channels. We will also investigate the functional relationships between sodium channels which carry a persistent Na+ current, and SLO2 Na+-activated channels. These experiments will be undertaken in a heterologous system where we will reconstitute a SLO2-sodium channel coupled system, and in experiments using single membrane patches from native neurons where the functional interactions of sodium channels and SLO2 channels can be studied under circumscribed conditions where sodium entry is limited to the patch.
Project Information
Project Name or Project/Program Title*: SLO2 K+ CHANNELS: A MAJOR SYSTEM CONTROLLING EXCITABILITY IN THE BRAIN
Project Status*: Recipient responsible for this data
Total Federal Amount of ARRA Funds Received/Invoiced*: Recipient responsible for this data
Number of Jobs*: Recipient responsible for this data
Description of Jobs Created*: Recipient responsible for this data
Quarterly Activities/Project Description*: Recipient responsible for this data
Activity Code (NAICS or NTEE-NPC)*: Recipient responsible for this data
Total Federal Amount of ARRA Expenditure* (Enter the cumulative total amount of Recovery Funds received that were expended to projects or activities. Refer to the Data Model for details on how to calculate this amount.): Recipient responsible for this data
Total Federal ARRA Infrastructure Expenditure Recipient responsible for this data
Infrastructure Contact Name: Recipient responsible for this data
Infrastructure Contact Email: Recipient responsible for this data
Infrastructure Contact Phone: Recipient responsible for this data
Infrastructure Contact Phone Ext: Recipient responsible for this data
Infrastructure Contact Street Address 1: CAMPUS BOX 1034
Infrastructure Contact Street Address 2: Not Available
Infrastructure Contact Street Address 3: Recipient responsible for this data
Infrastructure City: SAINT LOUIS
Infrastructure State: MO
Infrastructure ZIP Code+4: 63112
Infrastructure Purpose and Rationale (If applicable, enter an explanation about how the infrastructure investment will contribute to one or more purposes of the Recovery Act. Refer to the Data Model for details on what to report. 4000 characters or less.): Recipient responsible for this data
Primary Place of Performance
Street Address 1: 1 BROOKINGS DRIVECAMPUS BOX 1054
Street Address 2: ST. LOUIS
City*: ST. LOUIS
State*: MO
ZIP Code+4*: 631304899
Congressional District*: 1
Country*: US
Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability*: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
This concludes the current search. To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool Landing Page.
Use in the Recipient Report
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
