HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please email our help desk at Readiness Help
Prime Recipient Report
Award Detail for: HISTONE DEMETHYLATION A NOVEL MECHANISM IN HORMONE-MEDIATED GENE REGULATIONRecipient Name:BRIGHAM & WOMEN`S HOSPITAL
DUNS Number: 030811269
10 VINING STREET
BOSTON, MA 02115-6114
Reporting Information
Award Type*: Grant
Award Number*: 5R01DK077036-02
Final Report*: Recipient responsible for this data
Award Recipient Information
Recipient DUNS Number*: 030811269
Recipient Account Number: Recipient responsible for this data
Recipient Congressional District*: 8
Award Information
Funding Agency Code*: 7529
Awarding Agency Code*:7529
Award Date*: 07-12-2010
Amount of Award*: $ 431,605
Program Source (TAS)*: 750883
CFDA Number*: 93.701
Sub Account Number for Program Source (TAS)*: Recipient responsible for this data
Total Number of Sub Awards to Individuals*: Recipient responsible for this data
Total Amount of Sub Awards to Individuals*: Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award*: Recipient responsible for this data
Total Amount of Payments to Vendors less than $25,000/award*: Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award*: Recipient responsible for this data
Total Amount of Sub Awards less than $25,000/award*: Recipient responsible for this data
Award Description* DESCRIPTION (provided by applicant): Histone modifications provide a mechanism for regulating the diverse structural and functional features of chromatin, including control of gene regulation and maintenance of genomic integrity. Histone modifications play important roles in cell growth and survival, differentiation, embryonic development, and their related pathologies, including oncogenic transformation. Recently, we have made the exciting discovery of the first bona fide histone demethylase LSD1 (Lysine-Specific Demethylase 1). The identification of LSD1 as an H3-lysine 4 (H3-K4) specific histone demethylase revealed the reversible nature of histone methylation. It not only settled the longstanding debate regarding histone demethylation, but also represented a major advance in our understanding of epigenetic gene regulation. LSD1 has also been found in a variety of multi-subunit complexes involved in gene regulation. It is a coregulator for androgen receptor mediated gene regulation, suggesting that histone demethylation may serve as a fundamental mechanism for hormone action at the transcription level. The focus of our research is on the regulation of histone demethylase(s) and the biological consequences of histone demethylation in nuclear receptor mediated gene regulation. These are fundamental events in hormone-dependent biological processes and are important for stem cell differentiation and embryonic development. Using LSD1 as the first molecular model, we aim to define histone demethylation as a novel, yet widespread regulatory mechanism for steroid hormone receptor (e.g. androgen, glucocorticoid, and thyroid receptors) action on target genes. Data derived from these studies will contribute to the rapidly advancing and groundbreaking field of epigenetics. The findings from these studies will provide significant insights into the mechanisms underlying histone demethylation as it relates to nuclear hormone receptor mediated gene regulation. They will also greatly contribute to our understanding of hormone physiology and a variety of human pathologies, including tumorigenesis and developmental anomalies.Histone modifications provide a mechanism for regulating the diverse structural and functional features of chromatin, including control of gene regulation and maintenance of genomic integrity. Histone modifications play important roles in cell growth and survival, differentiation, embryonic development, and their related pathologies, including oncogenic transformation. The focus of our research is on the regulation of histone demethylase(s) and the biological consequences of histone demethylation in nuclear receptor mediated gene regulation. These are fundamental events in hormone-dependent biological processes and are important for stem cell differentiation and embryonic development.
Project Information
Project Name or Project/Program Title*: HISTONE DEMETHYLATION A NOVEL MECHANISM IN HORMONE-MEDIATED GENE REGULATION
Project Status*: Recipient responsible for this data
Total Federal Amount of ARRA Funds Received/Invoiced*: Recipient responsible for this data
Number of Jobs*: Recipient responsible for this data
Description of Jobs Created*: Recipient responsible for this data
Quarterly Activities/Project Description*: Recipient responsible for this data
Activity Code (NAICS or NTEE-NPC)*: Recipient responsible for this data
Total Federal Amount of ARRA Expenditure* (Enter the cumulative total amount of Recovery Funds received that were expended to projects or activities. Refer to the Data Model for details on how to calculate this amount.): Recipient responsible for this data
Total Federal ARRA Infrastructure Expenditure Recipient responsible for this data
Infrastructure Contact Name: Recipient responsible for this data
Infrastructure Contact Email: Recipient responsible for this data
Infrastructure Contact Phone: Recipient responsible for this data
Infrastructure Contact Phone Ext: Recipient responsible for this data
Infrastructure Contact Street Address 1: 10 VINING STREET
Infrastructure Contact Street Address 2: Not Available
Infrastructure Contact Street Address 3: Recipient responsible for this data
Infrastructure City: BOSTON
Infrastructure State: MA
Infrastructure ZIP Code+4: 02115-6114
Infrastructure Purpose and Rationale (If applicable, enter an explanation about how the infrastructure investment will contribute to one or more purposes of the Recovery Act. Refer to the Data Model for details on what to report. 4000 characters or less.): Recipient responsible for this data
Primary Place of Performance
Street Address 1: 221 LONGWOOD AVE
Street Address 2: BOSTON
City*: BOSTON
State*: MA
ZIP Code+4*: 2115
Congressional District*: Not Available
Country*: US
Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability*: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
- Officer Name and Compensation: Recipient responsible for this data
This concludes the current search. To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool Landing Page.
Use in the Recipient Report
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
