HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

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Prime Recipient Report

Award Detail for: THE EPIDEMIOLOGY OF HOME ALLERGENS AND ASTHMA
Recipient Name:BRIGHAM & WOMEN`S HOSPITAL
DUNS Number: 030811269
10 VINING STREET
BOSTON, MA 02115-6114

Reporting Information

Award Type*: Grant

Award Number*: 5R01AI035786-17

Final Report*: Recipient responsible for this data

Award Recipient Information

Recipient DUNS Number*: 030811269

Recipient Account Number: Recipient responsible for this data

Recipient Congressional District*: 8

Award Information

Funding Agency Code*: 7529

Awarding Agency Code*:7529

Award Date*: 06-21-2010

Amount of Award*: $ 852,814

Program Source (TAS)*: 750900

CFDA Number*: 93.701

Sub Account Number for Program Source (TAS)*: Recipient responsible for this data

Total Number of Sub Awards to Individuals*: Recipient responsible for this data

Total Amount of Sub Awards to Individuals*: Recipient responsible for this data

Total Number of Payments to Vendors less than $25,000/award*: Recipient responsible for this data

Total Amount of Payments to Vendors less than $25,000/award*: Recipient responsible for this data

Total Number of Sub Awards less than $25,000/award*: Recipient responsible for this data

Total Amount of Sub Awards less than $25,000/award*: Recipient responsible for this data

Award Description* Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood. We found reduced pro-inflammatory Th2 cytokine production at age 2, reduced risk of eczema, and subsequent reduced allergy/allergic rhinitis risk by age 7 in children with elevated levels in infancy of home endotoxin, the biologically active form of lipopolysaccharide (LPS) contained in the outer membrane of gram-negative bacteria. In contrast, elevated early- life levels of dust mite increased allergic sensitization and active asthma risk; elevated home fungal levels in infancy increased allergic rhinitis risk. Endotoxin was correlated with other microbial flora (e.g., muramic acid, a marker for gram + bacteria, fungi); it may be a marker for an array of exposures recognized by antigen presenting cells (APCs) as pathogen-associated-molecular patterns (PAMPS). Ligation of PAMPS to innate APCs or regulatory cells may result in downregulation of allergic adaptive immune responses, or may result in airway inflammation depending on dose, timing and genes. In preliminary analyses, elevated muramic acid and elevated endotoxin were both linked to asthma symptom protection at age 7, though paradoxically, endotoxin predicted increased infant wheeze. We propose to extend our prospective longitudinal study of children of asthmatic/allergic parents to examine multiple microbial PAMP influences on asthma and immune development, following our birth cohort through the early teen years, a period of significant transition for allergy and asthma. We hypothesize that by the early teen years: (1) Early life exposure to home endotoxin will be associated with protection against allergic rhinitis and allergic sensitization. The relationship of endotoxin to wheeze, asthma and the secondary phenotypes of airway obstruction and airway inflammation, will be dependent on dose, timing, persistence of exposure, and host factors. As a marker for multiple PAMPS, endotoxin will be correlated with muramic acid, which will have similar effects on allergic rhinitis, wheeze, asthma and allergic sensitization. (2) Early life exposure to home fungi will be a risk factor for allergic rhinitis, wheeze, asthma and allergic sensitization. Fungal irritant and allergenic effects will dominate over the potential protective effects of fungi as PAMPS. (3) Reduction in bacterial PAMP exposures will be linked to reduced innate (TLR2, TLR4, MyD88, sCD14, IL-12) and regulatory (foxp3, IL-10, TGF-¿) gene expression and cytokine production, which in turn will lead to reduced adaptive Th1 (IFN-¿) cytokine production, elevated pro-allergic Th2 (IL-4, IL-13) cytokine production and subsequent allergic sensitization. Understanding the evolution of the allergic immune response to microbial flora and correlated cofactors is an important key to developing better environmental or pharmacologic controls to either prevent or switch off the tendency to allergy and asthma in childhood.

Project Information

Project Name or Project/Program Title*: THE EPIDEMIOLOGY OF HOME ALLERGENS AND ASTHMA

Project Status*: Recipient responsible for this data

Total Federal Amount of ARRA Funds Received/Invoiced*: Recipient responsible for this data

Number of Jobs*: Recipient responsible for this data

Description of Jobs Created*: Recipient responsible for this data

Quarterly Activities/Project Description*: Recipient responsible for this data

Activity Code (NAICS or NTEE-NPC)*: Recipient responsible for this data

Total Federal Amount of ARRA Expenditure* (Enter the cumulative total amount of Recovery Funds received that were expended to projects or activities. Refer to the Data Model for details on how to calculate this amount.): Recipient responsible for this data

Total Federal ARRA Infrastructure Expenditure Recipient responsible for this data

Infrastructure Contact Name: Recipient responsible for this data

Infrastructure Contact Email: Recipient responsible for this data

Infrastructure Contact Phone: Recipient responsible for this data

Infrastructure Contact Phone Ext: Recipient responsible for this data

Infrastructure Contact Street Address 1: 10 VINING STREET

Infrastructure Contact Street Address 2: Not Available

Infrastructure Contact Street Address 3: Recipient responsible for this data

Infrastructure City: BOSTON

Infrastructure State: MA

Infrastructure ZIP Code+4: 02115-6114

Infrastructure Purpose and Rationale (If applicable, enter an explanation about how the infrastructure investment will contribute to one or more purposes of the Recovery Act. Refer to the Data Model for details on what to report. 4000 characters or less.): Recipient responsible for this data

Primary Place of Performance

Street Address 1: RESEARCH ADMINISTRATION75 FRANCIS ST

Street Address 2: BOSTON

City*: BOSTON

State*: MA

ZIP Code+4*: 2115

Congressional District*: 8

Country*: US

Recipient Highly Compensated Officers

Prime Recipient Indication of Reporting Applicability*: Recipient responsible for this data

1. Officer Name and Compensation: Recipient responsible for this data
2. Officer Name and Compensation: Recipient responsible for this data
3. Officer Name and Compensation: Recipient responsible for this data
4. Officer Name and Compensation: Recipient responsible for this data
5. Officer Name and Compensation: Recipient responsible for this data

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