HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

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Prime Recipient Report

Award Detail for: SELENOPROTEINS AS TARGETS FOR CANCER PREVENTION
Recipient Name:BRIGHAM & WOMEN`S HOSPITAL
DUNS Number: 030811269
10 VINING STREET
BOSTON, MA 02115-6114

Reporting Information

Award Type*: Grant

Award Number*: 3R01CA080946-10S1

Final Report*: Recipient responsible for this data

Award Recipient Information

Recipient DUNS Number*: 030811269

Recipient Account Number: Recipient responsible for this data

Recipient Congressional District*: 8

Award Information

Funding Agency Code*: 7529

Awarding Agency Code*:7529

Award Date*: 09-22-2009

Amount of Award*: $ 311,587

Program Source (TAS)*: 750850

CFDA Number*: 93.701

Sub Account Number for Program Source (TAS)*: Recipient responsible for this data

Total Number of Sub Awards to Individuals*: Recipient responsible for this data

Total Amount of Sub Awards to Individuals*: Recipient responsible for this data

Total Number of Payments to Vendors less than $25,000/award*: Recipient responsible for this data

Total Amount of Payments to Vendors less than $25,000/award*: Recipient responsible for this data

Total Number of Sub Awards less than $25,000/award*: Recipient responsible for this data

Total Amount of Sub Awards less than $25,000/award*: Recipient responsible for this data

Award Description* DESCRIPTION (provided by applicant): Selenium (Se) is an essential trace element in human nutrition due to its presence, in the form of selenocysteine residue, in 25 selenoproteins. Selenoproteins participate in diverse biological processes, but their key roles are to regulate cellular redox homeostasis. These redox activities are modulated by the level and chemical form of dietary Se in a selenoprotein- and organ-specific manner. Selenoprotein status has been implicated in a variety of physiological processes and diseases, but the function of Se that attracted the most attention is its role in cancer. There are numerous studies, including clinical trials, which support the role of Se in cancer prevention, but there are also studies that found no such role. The consensus is that Se may be beneficial under conditions of low Se status, when selenoprotein levels are suboptimal, whereas this micronutrient is not effective in cancer prevention when Se levels are above that needed to saturate selenoprotein expression. Our research revealed a dual role the 15 kDa selenoprotein (Sep15) in cancer. We hypothesize that Sep15 and its homolog selenoprotein M (SelM) serve as redox gatekeepers for disulfide-rich proteins that pass through the endoplasmic reticulum. This hypothesis will be addressed using cell culture and mouse models. We will determine redox targets of Sep15 and SelM, characterize consequences of their deficiency, profile immunoglobulins in selenoprotein knockout mice and examine their maturation status. In addition, we found that high-throughput analyses of selenoproteins in a large panel of human cancer cell lines provides direct insights into the functions of these proteins in the context of human cancer, control of redox homeostasis and dependence of various cancer types on selenoproteins. We will characterize the human selenoproteome and selenocysteine machinery for their roles in human cancer by analyzing coexpression patterns and dependence of various cancer types on selenoproteins and drugs, and will link this information with genotype and expression patterns. This information will define the roles of selenoproteins in human cancer and provide critical information for the development of approaches for personalized use of dietary selenium to modulate cancer prevention and progression. Overall, these studies will provide critical insights into the role of selenium and selenoproteins in cancer. PUBLIC HEALTH RELEVANCE: Mechanisms by which the trace element selenium affects cancer incidence are not known. We propose to functionally characterize selenoproteins that are thought to mediate the effect of selenium in cancer prevention and progression. We will also examine selenoprotein functions and regulation in the context of human cancer.

Project Information

Project Name or Project/Program Title*: SELENOPROTEINS AS TARGETS FOR CANCER PREVENTION

Project Status*: Recipient responsible for this data

Total Federal Amount of ARRA Funds Received/Invoiced*: Recipient responsible for this data

Number of Jobs*: Recipient responsible for this data

Description of Jobs Created*: Recipient responsible for this data

Quarterly Activities/Project Description*: Recipient responsible for this data

Activity Code (NAICS or NTEE-NPC)*: Recipient responsible for this data

Total Federal Amount of ARRA Expenditure* (Enter the cumulative total amount of Recovery Funds received that were expended to projects or activities. Refer to the Data Model for details on how to calculate this amount.): Recipient responsible for this data

Total Federal ARRA Infrastructure Expenditure Recipient responsible for this data

Infrastructure Contact Name: Recipient responsible for this data

Infrastructure Contact Email: Recipient responsible for this data

Infrastructure Contact Phone: Recipient responsible for this data

Infrastructure Contact Phone Ext: Recipient responsible for this data

Infrastructure Contact Street Address 1: 10 VINING STREET

Infrastructure Contact Street Address 2: Not Available

Infrastructure Contact Street Address 3: Recipient responsible for this data

Infrastructure City: BOSTON

Infrastructure State: MA

Infrastructure ZIP Code+4: 02115-6114

Infrastructure Purpose and Rationale (If applicable, enter an explanation about how the infrastructure investment will contribute to one or more purposes of the Recovery Act. Refer to the Data Model for details on what to report. 4000 characters or less.): Recipient responsible for this data

Primary Place of Performance

Street Address 1: HARVARD NEW RESEARCH BUILDING 4TH FLOOR 75 FRANCIS ST

Street Address 2: BOSTON

City*: BOSTON

State*: MA

ZIP Code+4*: 02115

Congressional District*: 8

Country*: US

Recipient Highly Compensated Officers

Prime Recipient Indication of Reporting Applicability*: Recipient responsible for this data

1. Officer Name and Compensation: Recipient responsible for this data
2. Officer Name and Compensation: Recipient responsible for this data
3. Officer Name and Compensation: Recipient responsible for this data
4. Officer Name and Compensation: Recipient responsible for this data
5. Officer Name and Compensation: Recipient responsible for this data

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