HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please email our help desk at Readiness Help

Prime Recipient Report

Award Detail for: REPAIR OF CLUSTERED DNA DAMAGES
Recipient Name:EMORY UNIVERSITY
DUNS Number: 066469933
1784 N DECATUR RD,S 530 NDBLDG
ATLANTA, GA 30322-1048

Reporting Information

Award Type*: Grant

Award Number*: 5R01CA090860-06

Final Report*: Recipient responsible for this data

Award Recipient Information

Recipient DUNS Number*: 066469933

Recipient Account Number: Recipient responsible for this data

Recipient Congressional District*: 5

Award Information

Funding Agency Code*: 7529

Awarding Agency Code*:7529

Award Date*: 07-26-2010

Amount of Award*: $ 238,877

Program Source (TAS)*: 750850

CFDA Number*: 93.701

Sub Account Number for Program Source (TAS)*: Recipient responsible for this data

Total Number of Sub Awards to Individuals*: Recipient responsible for this data

Total Amount of Sub Awards to Individuals*: Recipient responsible for this data

Total Number of Payments to Vendors less than $25,000/award*: Recipient responsible for this data

Total Amount of Payments to Vendors less than $25,000/award*: Recipient responsible for this data

Total Number of Sub Awards less than $25,000/award*: Recipient responsible for this data

Total Amount of Sub Awards less than $25,000/award*: Recipient responsible for this data

Award Description* Melanoma is the fifth and seventh most commonly diagnosed cancer in America men and women. The molecular and genetic basis for the formation of melanoma is still largely unclear. The majority of melanoma (90%) is of sporadic origin, and only about 10% appears to have familial clustering. Familiar melanoma has been observed to be associated with CDKN2a/ARF and CDK mutations. In contract, a high proportion of the sporadic melanoma shows mutation in the N-RAS and B-RAF gene. B-RAF mutations, in particular mutations in exon 15 were found to be associated with greater than 65% of melanoma. It is of interest to note that more than 90% of B-RAF mutations at exon 15 occur at V599. The predominant mutation signature at V599 is T to A transversion mutation (GTG to GAG), changing valine to aspartic acid. Tandem mutation at GTG(V599) site can account for up to 30 % of the B-RAF mutations observed in primary invasive melanoma. B-RAF mutations also occur at relatively high frequency (70-80%) in melanocytic nevi, but not the surrounding tissue. It is clear that UV exposure is a major etiological risk factor for cutaneous melanoma(CM); however, UV is not sufficient for the generation of the unique B-RAF mutation that is present in high frequencies in melanocytic nevi and melanoma. Genetic and environmental (occupational?) factors are potentially contributing to the development of sporadic melanoma and the appearance of the unique B-RAF mutation. We will focus on identifying the potential environmental and genetic factors that might cooperate with UV that lead to the generation of the unique V599 mutation. Two cell lines will be used for the proposed research, the immortalized normal keratinocytes, HaCat cells and immortalized normal melanocytes, PIG1 cells. These two cell lines will be exposed to various genotoxicants, singly or in combination with UV exposure. The mutation frequency and spectrum at the V599 codon will be determined for the mutants generated in both cell lines. Comparison of the mutation frequency and spectrum at V599 codon generated in these two cell lines is expected to help to delineate the potential agents that will lead to the generation of expected double mutations generated only in melanocytes and not in keratinocytes. In order to determine the potential genetic factors that might be involved, we will use siRNA to knockdown various DNA repair genes in both HaCat and PIG1 cells and determine which DNA repair enzyme plays a role in the generation of the unique V599 mutation. The mutation frequency will be determined by the random mutation assay developed by Loeb's. The mutation spectrum at the V599 codon will be obtained by DNA sequencing of PCR fragments generated from the mutant cells that harbor the V599 mutation. Completion of the proposed research is expected to yield crucial information on the nature of the potential environmental agents that play an essential role in the formation of melanoma. In addition, it will provide significant insight as to the potential mechanism involved in melanoma progression.

Project Information

Project Name or Project/Program Title*: REPAIR OF CLUSTERED DNA DAMAGES

Project Status*: Recipient responsible for this data

Total Federal Amount of ARRA Funds Received/Invoiced*: Recipient responsible for this data

Number of Jobs*: Recipient responsible for this data

Description of Jobs Created*: Recipient responsible for this data

Quarterly Activities/Project Description*: Recipient responsible for this data

Activity Code (NAICS or NTEE-NPC)*: Recipient responsible for this data

Total Federal Amount of ARRA Expenditure* (Enter the cumulative total amount of Recovery Funds received that were expended to projects or activities. Refer to the Data Model for details on how to calculate this amount.): Recipient responsible for this data

Total Federal ARRA Infrastructure Expenditure Recipient responsible for this data

Infrastructure Contact Name: Recipient responsible for this data

Infrastructure Contact Email: Recipient responsible for this data

Infrastructure Contact Phone: Recipient responsible for this data

Infrastructure Contact Phone Ext: Recipient responsible for this data

Infrastructure Contact Street Address 1: 1784 N DECATUR RD,S 530 NDBLDG

Infrastructure Contact Street Address 2: Not Available

Infrastructure Contact Street Address 3: Recipient responsible for this data

Infrastructure City: ATLANTA

Infrastructure State: GA

Infrastructure ZIP Code+4: 30322-1048

Infrastructure Purpose and Rationale (If applicable, enter an explanation about how the infrastructure investment will contribute to one or more purposes of the Recovery Act. Refer to the Data Model for details on what to report. 4000 characters or less.): Recipient responsible for this data

Primary Place of Performance

Street Address 1: ROOM 5305B

Street Address 2: ATLANTA

City*: ATLANTA

State*: GA

ZIP Code+4*: 30322

Congressional District*: 5

Country*: US

Recipient Highly Compensated Officers

Prime Recipient Indication of Reporting Applicability*: Recipient responsible for this data

1. Officer Name and Compensation: Recipient responsible for this data
2. Officer Name and Compensation: Recipient responsible for this data
3. Officer Name and Compensation: Recipient responsible for this data
4. Officer Name and Compensation: Recipient responsible for this data
5. Officer Name and Compensation: Recipient responsible for this data

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