HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R21HD061778-02 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 041907486 | Recipient responsible for this data | 18 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 08-31-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 214,650 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750840 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Intraventricular hemorrhage (IVH) in premature infants predisposes to white matter injury and subsequent cerebral palsy. The most common white matter injury in premature infants is 'gliosis and hypomyelination with intact axons'. In our model of IVH in premature rabbits, there is an arrest of oligodendrocyte (OL) maturation at a pre-myelinating stage. However, the mechanism underlying the maturational arrest of pre-OL and subsequent hypomyelination is unclear. Myelination is a dynamic process that needs an appropriate microenvironment containing growth factors, extracellular matrix molecules and myelinating OL. Chrondroitin sulfate proteoglycans (CSPG)-- neuracan, phosphacan, brevican, decorin, NG2 & versican--are important components of the extracellular matrix (ECM) and are increased in adult and neonatal brain injuries. They are primarily produced by reactive astrocytes and are regulated by transforming growth factor-2 (TGF-2) and epidermal growth factor (EGF). CSPGs have key regulatory functions during migration, proliferation and differentiation of pre-OL. Specifically, degradation of CSPGs by either chondroitinase or protease facilitates migration of OL, loosens the physical barriers in ECM, enhances formation of OL process outgrowths to unsheathe axons and improves interaction of growth factors with OL. Despite this evidence, direct effect(s) of CSPGs on myelination have not been studied. We hypothesize that CSPGs are elevated in premature newborns with IVH and that suppression of CSPG formation will restore myelination of axons and maturation of pre- OL into myelinating OL. Our preliminary data show that expression of CSPGs and growth factors (TGF2 and EGF) are elevated in premature infants and rabbit pups with IVH; and treatment with decorin, a CSPG and natural antagonist of TGF-2, reduces their levels. Our approach is to use a rabbit model that induces IVH with intraperitoneal glycerol. This model results in pups with hemorrhage to exhibit inflammation, cell death and subsequently, lesser myelination and more enhanced gliosis (day 14) compared to controls without IVH. The following specific aims will be addressed: Aim #1. Determine whether the expression of CSPGs (neuracan, phosphacan, brevican, decorin, NG2 & versican) and their regulating growth factors (TGF-2 and EGF) are higher in both premature rabbit pups and infants with IVH compared to controls without IVH. Aim # 2. Determine whether suppression of CSPGs either by chondroitinase or decorin (via TGF-2 inhibition) facilitates maturation of pre-OL, myelination and neurological recovery in premature rabbit pups with IVH. Our study that links CSPGs with failure to myelinate coupled with our novel approaches to regulate CSPG expression may provide effective strategies for prevention of cerebral palsy in infants with IVH. PUBLIC HEALTH RELEVANCE: In the United States, about 12,240 premature infants develop bleeding in and around the ventricle (cavity) of the brain each year, which enhances the risk of white matter injuries and consequent cerebral palsy (weakness in extremities), and cognitive deficits--writing and reading difficulties. In this proposal, we seek to determine the mechanism of brain injuries in these infants with hemorrhage that leads to impairment in walking, reading and writing. In addition, we will test therapeutic strategies that can minimize or prevent cerebral palsy in them. To address these issues, we will use prematurely delivered rabbit pups as an experimental animal and will also use autopsy materials from premature infants with and without brain hemorrhage. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| CHONDROITIN SULFATE PROTEOGLYCAN AND MYELINATION IN INTRAVENTRICULAR HEMORRHAGE | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| ADMINISTRATION BUILDING | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| VALHALLA | NY | 10595 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 40 SUNSHINE COTTAGE ROAD | Recipient responsible for this data | VALHALLA |
| State | Zip Code+4 | Congressional District |
| NY | 10595 | 18 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
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USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
