HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R21AR057200-02 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 555917996 | Recipient responsible for this data | 5 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 08-03-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 169,877 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750903 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| Description (provided by applicant): The interaction of keratinocytes and epidermal nerve fibers has emerged as an important interface in sensory transduction and pain and may be a factor in the mechanisms underlying painful peripheral neuropathies. Keratinocytes express receptors and channels that enable them to "sense" mechanical and thermal stimuli and transmit signals to epidermal nerve fibers through the release of messenger molecules. Growth factors and cytokines secreted from keratinocytes are also likely to impact long-term changes within the sensory neurons that innervate epidermis. Conversely, neuropeptides contained within sensory neurons have the ability to modulate keratinocytes, including their production and secretion of cytokines and growth factors. Partial peripheral nerve injury that leads to neuropathic pain is associated with degeneration of injured nerve fibers and altered function of adjacent uninjured fibers. The impact of altered epidermal innervation on the dynamic neuro-keratinocyte relationship is unknown. The objective of this R21 proposal is to determine the effects of epidermal innervation on keratinocyte protein expression and function. Specific Aim 1 will address the hypothesis that nerve injury-induced changes in innervation will alter keratinocyte protein expression and function. Epidermal innervation and nerve injury- induced hypersensitivity will be correlated with keratinocyte expression of receptors and channels implicated in sensory transduction as well as cytokines known to sensitize sensory neurons. Functional changes in epidermis will be evaluated based on measurement of keratinocyte ATP release. Specific Aim 2 will determine the effects of sensory neurons on protein expression and function of keratinocytes in organotypic culture where neuronal input will be introduced by co-culture with sensory neurons. These experiments will address the hypothesis that selected subsets of sensory neurons will have differential effects on keratinocytes. Biochemical approaches will be used to identify candidate mediators of neuro-keratinocyte signaling. Changes in the dynamic neuro-keratinocyte relationship following nerve injury may contribute to neuropathic pain mechanisms through sensitization of surviving epidermal nerve fibers and changes in keratinocyte transduction of sensory stimuli. Therefore, neuro-keratinocyte interactions and their modulation by nerve injury represent a previously unexplored component of the pathobiological consequences of nerve injury, and their understanding may lead to identification of novel peripheral therapeutic targets for neuropathic pain. PUBLIC HEALTH RELEVANCE: The proposed project will analyze the interaction between two important structures in the transmission of sensory information: sensory nerves and the epidermis of the skin. These studies will identify a pattern of keratinocyte changes associated with nerve injury that will provide a foundation for in-depth analysis of the contribution of neuro-keratinocyte interactions to pain. Manipulation of these interactions may be able to provide a peripherally restricted therapeutic strategy. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| ANALYSIS OF NEURO-EPIDERMAL INTERACTIONS | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 106 PLEASANT SE, 210 FRASER HL | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| MINNEAPOLIS | MN | 55455 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 321 CHURCH ST. SE | Recipient responsible for this data | MINNEAPOLIS |
| State | Zip Code+4 | Congressional District |
| MN | 55455 | 5 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
