HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R03AI079478-02 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 041544081 | Recipient responsible for this data | 15 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 05-19-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 71,826 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750900 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): This application from a collaboration between the Seufferheld and Blanke laboratories at the University of Illinois at Urbana-Champaign proposes studies to explore the overall hypothesis that Helicobacter pylori acidocalcisome-like granule (ALGs) are polyphosphate-rich organelles. Dense volutin granules have been previously described in the cytosol of H. pylori, which several lines of evidence suggest are acidocalcisomes, and which we tentatively describe as acidocalcisome-like granules (ALGs). Acidocalcisomes are membrane-bound organelles localized to the cytosol of several eukaryotic microorganisms. The recent discovery of acidocalcisomes in bacteria, in which the PI was the first to identify bacterial acidocalcisomes, is exciting because it is one of the first examples of a membrane bound organelle within bacteria, and supports an important functional role for acidocalcisomes across prokaryotic and eukaryotic kingdoms. The association of acidocalcisomes with the synthesis of polyphosphate (poly P) polymers has been established in eukaryotes. Poly P is associated with multiple functions in bacteria, and has important roles in bacterial pathogenesis for multiple pathogens, including the important human gastric pathogen H. pylori, the etiologic agent of several important gastric diseases. The capacity of H. pylori to successfully colonize and persist within the stomach requires that the organism survive the harsh conditions of this host niche. Notably, poly P has been demonstrated to be important for colonization of H. pylori within a murine infection model, as well as for stress resistance, in vitro. However, the mechanisms underlying this relationship between poly P and H. pylori stress resistance and virulence have not been studied, and remain poorly understood. Our long-term goal is to identify and characterize the mechanisms underlying poly P regulation and accumulation within H. pylori, as well as to understand the physiological role of ALGs and poly P in the physiology and pathogenesis of this important human pathogen. However, in order to reach these long-term goals in the future, it is first critical to validate that the dense volutin granules previously described in H. pylori are poly P-enriched ALGs. In this R03 application, we propose detailed studies to isolate and purify ALGs from H. pylori. We will evaluate the ALGs for known markers of acidocalcisomes and/or poly P metabolism. The studies supported by this R03 mechanism are important for establishing the experimental and conceptual framework for future studies to investigate the molecular composition and roles of ALGs in virulence for an important human pathogen. PUBLIC HEALTH RELEVANCE: Long-term infection with the human pathogen Helicobacter pylori is a significant risk factor for the development of gastric ulcer disease or gastric adenocarcinoma, one of the leading causes of cancer-related death worldwide. The completion of the research proposed within this application is critical for revealing fundamental new information about how this important human pathogen survives the harsh environment of the stomach, which in turn may reveal new targets for antibiotic development. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| PPK DEPENDENT ACIDOCALCISOME-LIKE GRANULES, POLYPHOSPHATES AND HELICOBACTER | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 109 COBLE HALL, 801 S WRIGHT S | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| CHAMPAIGN | IL | 61820 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| OF SPONSORED PROGRAMS & RESEARCH ADMIN1901 S. FIRST STREET, SUITE A, MC-685 | Recipient responsible for this data | CHAMPAIGN |
| State | Zip Code+4 | Congressional District |
| IL | 61820 | 15 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
