HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R01HL071782-06 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 068552207 | Recipient responsible for this data | 1 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 06-16-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 937,040 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750871 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| Hypertension (HTN), a disease that affects over 65 million Americans, is one of the most common chronic diseases in the world. Hypertensive heart disease (HHD) phenotypes, including left ventricular (LV) hypertrophy (LVH), LV diastolic dysfunction (LVDD), LV systolic dysfunction (LVSD), and vascular hypertrophy are common and inter-related. Furthermore, HHD-endophenotypes are commonly worsened by co-morbid conditions such as diabetes, obesity, metabolic syndrome, and dyslipidemia, thus suggesting that common underlying pathologic processes control/modulate these phenotypes through gene-gene (GxG) and/or gene-environment (GxE) interactions. During the first 5 years of this project, the investigative team has identified genes involved in myocardial metabolism and inflammation as putative modulators of these highly complex HHD-related phenotypes. The overarching hypothesis of this study is that in HTN, metabolic-inflammatory gene pathways interact to develop HHD-endophenotypes. This hypothesis will be tested by conducting a phenotype-genotype clinical study in 1,650 unrelated Caucasians by performing a high-density genome-wide association (GWA) study where single nucleotide polymorphisms (SNPs) will be associated with quantitative HHD-endophenotypes. The existing DNA repository includes exquisite, quantitative cardiovascular, metabolic, environmental, and inflammatory phenotypes ideal for association studies of the genetic/molecular basis of HTN/HHD-endophenotypes. The hypothesis is supported by studies in animal models of HHD conducted by collaborators at our institution and others. We have assembled a multidisciplinary team with expertise in clinical/translational research, molecular cardiology, and statistical genetics/genetic epidemiology, and build upon an existing comprehensive repository of DNAs and arrays of exquisite clinical phenotypes in 1000 Caucasian subjects. The revised specific aims (SA) for this two-year project are SA1. Enhance existing study cohort of 1,000 subjects by recruiting and phenotyping an additional 300 subjects to achieve a study population of 1,300 Caucasians. SA2. Perform integrated GWA analysis to develop a global survey of SNPs in pathways relevant for the development of HHD-endophenotypes in the Caucasian cohort. Exploratory Specific Aim. Select 2 top-ranked interacting candidate genes, one from each network, for fine-mapping of HHD variants by deep resequencing. GWA data from the primary and validation studies will lead to the construction of an HHD-pathways resource database. This research will result in a clear understanding of HHD and will generate the first database of highly dense SNP genotypes augmented by pathway information for future studies of HTN/HHD-endophenotypes. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| GENETIC DETERMINANTS OF THE LVH PHENOTYPE | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| CAMPUS BOX 1034 | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| SAINT LOUIS | MO | 63112 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 660 SOUTH EUCLID AVENUE | Recipient responsible for this data | ST. LOUIS |
| State | Zip Code+4 | Congressional District |
| MO | 63110 | Not Available |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
