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HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

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Award Detail for: HISTONE DEMETHYLATION A NOVEL MECHANISM IN HORMONE-MEDIATED GENE REGULATION
BRIGHAM & WOMEN`S HOSPITAL
DUNS Number: 030811269
10 VINING STREET
BOSTON, MA 02115-6114
Recipient Report: Grant or Loan
Prime Recipient

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Reporting Information
Award Type Award Number Final Report
Grant 5R01DK077036-02 Recipient responsible for this data

Award Recipient Information
Recipient DUNS Number Recipient Account Number Recipient Congressional District
030811269 Recipient responsible for this data 8

Award Information
Funding Agency Code Awarding Agency Code Award Date
7529 7529 07-12-2010
Amount of Award Sub Account Number for Program Source (TAS)  
$ 431,605 Recipient responsible for this data
Program Source (TAS)* CFDA Number 
750883 93.701
Total Number of Sub Awards to Individuals Total Amount of Sub Awards to Individuals
Recipient responsible for this data Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award Total Amount of Payments to Vendors less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award Total Amount of Sub Awards less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Award Description
DESCRIPTION (provided by applicant): Histone modifications provide a mechanism for regulating the diverse structural and functional features of chromatin, including control of gene regulation and maintenance of genomic integrity. Histone modifications play important roles in cell growth and survival, differentiation, embryonic development, and their related pathologies, including oncogenic transformation. Recently, we have made the exciting discovery of the first bona fide histone demethylase LSD1 (Lysine-Specific Demethylase 1). The identification of LSD1 as an H3-lysine 4 (H3-K4) specific histone demethylase revealed the reversible nature of histone methylation. It not only settled the longstanding debate regarding histone demethylation, but also represented a major advance in our understanding of epigenetic gene regulation. LSD1 has also been found in a variety of multi-subunit complexes involved in gene regulation. It is a coregulator for androgen receptor mediated gene regulation, suggesting that histone demethylation may serve as a fundamental mechanism for hormone action at the transcription level. The focus of our research is on the regulation of histone demethylase(s) and the biological consequences of histone demethylation in nuclear receptor mediated gene regulation. These are fundamental events in hormone-dependent biological processes and are important for stem cell differentiation and embryonic development. Using LSD1 as the first molecular model, we aim to define histone demethylation as a novel, yet widespread regulatory mechanism for steroid hormone receptor (e.g. androgen, glucocorticoid, and thyroid receptors) action on target genes. Data derived from these studies will contribute to the rapidly advancing and groundbreaking field of epigenetics. The findings from these studies will provide significant insights into the mechanisms underlying histone demethylation as it relates to nuclear hormone receptor mediated gene regulation. They will also greatly contribute to our understanding of hormone physiology and a variety of human pathologies, including tumorigenesis and developmental anomalies.Histone modifications provide a mechanism for regulating the diverse structural and functional features of chromatin, including control of gene regulation and maintenance of genomic integrity. Histone modifications play important roles in cell growth and survival, differentiation, embryonic development, and their related pathologies, including oncogenic transformation. The focus of our research is on the regulation of histone demethylase(s) and the biological consequences of histone demethylation in nuclear receptor mediated gene regulation. These are fundamental events in hormone-dependent biological processes and are important for stem cell differentiation and embryonic development.

Project Information
Project Name or
Project/Program Title
Project Status Total Federal Amount ARRA Funds
Received/Invoiced
HISTONE DEMETHYLATION A NOVEL MECHANISM IN HORMONE-MEDIATED GENE REGULATION Recipient responsible for this data Recipient responsible for this data
Number of Jobs Description of Jobs Created
Recipient responsible for this data Recipient responsible for this data
Quarterly Activities/Project Description
Recipient responsible for this data
 
Activity Code (NAICS or NTEE-NPC)
1Recipient responsible for this data2Recipient responsible for this data
3Recipient responsible for this data4Recipient responsible for this data
5Recipient responsible for this data6Recipient responsible for this data
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Total Federal Amount of ARRA
Expenditure
Total Federal ARRA
Infrastructure Expenditure
Infrastructure Contact Name
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Email Infrastructure Contact Phone Infrastructure Contact Phone Ext.
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Street Address 1 Infrastructure Contact Street Address 2 Infrastructure Contact Street Address 3
10 VINING STREET Not Available Recipient responsible for this data
Infrastructure City Infrastructure State Infrastructure ZIP Code+4
BOSTON MA 02115-6114
Infrastructure Purpose and Rationale
Recipient responsible for this data

Primary Place of Performance
Street Address 1 Street Address 2 City
221 LONGWOOD AVE Recipient responsible for this data BOSTON
State Zip Code+4 Congressional District
MA 2115 Not Available
Country  
US

Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability # Officer Name Officer Compensation
Recipient responsible for this data 1 Recipient responsible for this data Recipient responsible for this data
2 Recipient responsible for this data Recipient responsible for this data
3 Recipient responsible for this data Recipient responsible for this data
4 Recipient responsible for this data Recipient responsible for this data
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