HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R01CA090860-06 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 066469933 | Recipient responsible for this data | 5 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 07-26-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 238,877 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750850 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| Melanoma is the fifth and seventh most commonly diagnosed cancer in America men and women. The molecular and genetic basis for the formation of melanoma is still largely unclear. The majority of melanoma (90%) is of sporadic origin, and only about 10% appears to have familial clustering. Familiar melanoma has been observed to be associated with CDKN2a/ARF and CDK mutations. In contract, a high proportion of the sporadic melanoma shows mutation in the N-RAS and B-RAF gene. B-RAF mutations, in particular mutations in exon 15 were found to be associated with greater than 65% of melanoma. It is of interest to note that more than 90% of B-RAF mutations at exon 15 occur at V599. The predominant mutation signature at V599 is T to A transversion mutation (GTG to GAG), changing valine to aspartic acid. Tandem mutation at GTG(V599) site can account for up to 30 % of the B-RAF mutations observed in primary invasive melanoma. B-RAF mutations also occur at relatively high frequency (70-80%) in melanocytic nevi, but not the surrounding tissue. It is clear that UV exposure is a major etiological risk factor for cutaneous melanoma(CM); however, UV is not sufficient for the generation of the unique B-RAF mutation that is present in high frequencies in melanocytic nevi and melanoma. Genetic and environmental (occupational?) factors are potentially contributing to the development of sporadic melanoma and the appearance of the unique B-RAF mutation. We will focus on identifying the potential environmental and genetic factors that might cooperate with UV that lead to the generation of the unique V599 mutation. Two cell lines will be used for the proposed research, the immortalized normal keratinocytes, HaCat cells and immortalized normal melanocytes, PIG1 cells. These two cell lines will be exposed to various genotoxicants, singly or in combination with UV exposure. The mutation frequency and spectrum at the V599 codon will be determined for the mutants generated in both cell lines. Comparison of the mutation frequency and spectrum at V599 codon generated in these two cell lines is expected to help to delineate the potential agents that will lead to the generation of expected double mutations generated only in melanocytes and not in keratinocytes. In order to determine the potential genetic factors that might be involved, we will use siRNA to knockdown various DNA repair genes in both HaCat and PIG1 cells and determine which DNA repair enzyme plays a role in the generation of the unique V599 mutation. The mutation frequency will be determined by the random mutation assay developed by Loeb's. The mutation spectrum at the V599 codon will be obtained by DNA sequencing of PCR fragments generated from the mutant cells that harbor the V599 mutation. Completion of the proposed research is expected to yield crucial information on the nature of the potential environmental agents that play an essential role in the formation of melanoma. In addition, it will provide significant insight as to the potential mechanism involved in melanoma progression. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| REPAIR OF CLUSTERED DNA DAMAGES | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 1784 N DECATUR RD,S 530 NDBLDG | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| ATLANTA | GA | 30322-1048 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| ROOM 5305B | Recipient responsible for this data | ATLANTA |
| State | Zip Code+4 | Congressional District |
| GA | 30322 | 5 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
