HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R01CA061010-15 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 143983562 | Recipient responsible for this data | Not Available |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 06-25-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 384,052 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750850 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Tumor progression, and particularly that of some neuroectodermal tumors (e.g., neuroblastoma and melanoma) causes most cancer-related morbidity and mortality. Thus, understanding and preventing progression is critical to developing effective cancer therapies. The synthesis and shedding of the membrane glycosphingolipids, gangliosides, has been strongly implicated by our past findings and the work of others in contributing to processes that facilitate tumor progression. Moreover, we have made significant progress in elucidating basic mechanisms in vitro by which gangliosides modulate the behavior of host cells found in the tumor microenvironment. We obtained clear evidence for the impact of ganglioside synthesis and shedding on cell signaling and on angiogenic responses of human endothelial cells, and found that pharmacological inhibition of glycosphingolipid synthesis has a striking inhibitory effect upon tumor growth. Based on these findings we hypothesize that gangliosides enhance tumor progression in vivo, and that interference with the synthesis of tumor gangliosides will impede tumor progression in vivo. However, an adequate animal model system of specific and constitutive inhibition of ganglioside synthesis in vivo has been lacking, and here we propose to fill this gap, by studying tumor progression in two different and complementary novel animal model systems that we are creating. In aim 1 we will develop two oncogene transformed ganglioside-deficient fibroblast tumor cell lines, one by GM3synthase/GM2synthase double knockout and the other by 4-OH-tamoxifen-inducible, cre-mediated deletion of glucosylceramide synthase (GCS). In aim 2 we will develop a unique ganglioside-depleted rodent tumor model by cre-mediated excision of the GCS gene in an orthotopic neuroectodermal (transgenic melanoma) tumor system in vivo. In Aim 3 we will comprehensively determine how ganglioside knockout in these ganglioside-depleted tumor systems affects tumor progression, providing the first unambiguous insights in vivo in a genetically controlled and stable system. Accomplishment of these aims will begin to elucidate the role and basic mechanisms by which gangliosides modulate tumor progression in vivo. This knowledge will lead to our ultimate goals of full delineation of the biological activity of tumor gangliosides in tumor progression and the development of novel therapeutic approaches to human cancer built upon this knowledge. PUBLIC HEALTH RELEVANCE: Understanding and prevention of tumor progression is critical for development of effective cancer therapies. The goal of the research proposed in this application is to determine exactly how production and shedding by tumor cells of a special type of lipids, named gangliosides, helps tumors to grow. The results of our studies will potentially allow modulation of ganglioside production/activity by tumors, which will in turn enable design of novel and effective treatments of cancer patients. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| ROLE OF GANGLIOSIDES IN TUMOR PROGRESSION | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 111 MICHIGAN AVENUE, NW | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| WASHINGTON | DC | 20010-2978 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 111 MICHIGAN AVENUE NW | Recipient responsible for this data | WASHINGTON |
| State | Zip Code+4 | Congressional District |
| DC | 20010 | 98 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
