HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5F31AI084460-02 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 066469933 | Recipient responsible for this data | 5 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 06-03-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 29,328 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750900 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): We have found that HIV-1 transgenic rats and HIV-1-treated co-cultures containing human pulmonary artery endothelial cells (HPAEC) and peripheral blood mononuclear cells (PBMC) demonstrate striking increases in arachidonate 5-lipoxygenase (AL0X5) mRNA expression. AL0X5 is the enzyme that produces leukotrienes (LT) from arachidonic acid. These LT include LTB4 and the potent vasoconstrictors, LTC4, LTD4 and LTE4. We believe HIV-induced increases in AL0X5 expression could yield elevated LT levels and potentially contribute to the progression of PAH, a disorder characterized by pulmonary vasoconstriction and vascular remodeling, by inducing vasoconstriction of the pulmonary vasculature. Previous works suggest that HIV-1 may play a role in PAH pathogenesis through the release of various virus-associated mediators and not through direct vascular contact. One potential mechanism in the etiology of HIV-associated PAH may exist in the effect of HlV-1 secreted proteins, such as Tat, Nef or gp120. Numerous works have described the effect of HIV-1 protein exposure on human endothelial cells showing increased gene and protein expression of various vasoactive molecules. These studies suggest an active link between HIV-1 proteins and the development of disorders affecting the vasculature. Therefore, we hypothesize that the HIV-1 protein(s) may contribute to HIV-PAH development by altering AL0X5 expression and leukotriene production. To test this hypothesis, we will employ cell cultures and a HIV-1 transgenic (Tg) rat model. Human pulmonary artery endothelial cells will be cultured in the presence or absence of HlV-1 proteins for various exposure times. AL0X5 transcription will be assessed by real-fime PCR and nuclear run-on assays. AL0X5 protein expression and leukotriene producfion will be assessed by western blot and ELISA, respectively. We will also investigate the role of AL0X5 in HIV-PAH progression by administering the AL0X5 inhibitor, Zileuton to HlV-1 Tg rats in the presence or absence of hypoxia. Therefore, in this study, we aim to 1) determine the HIV-1 protein(s) that mediate alterations in endothelial AL0X5 expression and activity and 2) assess the role of AL0X5 in HIV-related PAH. These analyses will lead to a better understanding of HIV-PAH and may yield future preventative measures and therapies for HIV-PAH and PAH sufferers. Moreover, these studies may elucidate ALOX5 expression as a potential biomarker of HIV-PAH disease development and severity. PUBLIC HEALTH RELEVANCE: As a fellowship recipient, I aim to participate in publication, proposal and grant-writing workshops. The ability to write clearly and concisely plays a critical role in academia and is an essential tool in becoming a successful scientific investigator. I also plan to participate in a variety of teaching opportunities. As an aspiring college professor, it is incredibly vital to be skilled at conveying information to others in an engaging manner In addition this fellowship will prove especially helpful in the completion of my dissertation and transition to an academic faculty member. The last two years will coincide with the senior segment of my graduate education. At this stage, it will become imperative that I utilize the available mentorships to assist me in obtaining postdoctoral appointments. Following the completion of my doctoral degree, I plan to obtain a postdoctoral position in a prominent laboratory studying pulmonary vascular disease. During this time, I plan to acquire further research training and experience teaching at the collegiate level. Attaining a professoriate position at a minority-serving institution is a long-term goal and personal career objective. It is very important that well-qualified and passionate teachers and professors remain a staple in today's schools and universities. These academic faculty members play a critical role in inspiring our youth to become the next generation of teachers, scientists, and doctors. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| HIV-INDUCED 5-LIPOXYGENASE: ROLE IN HIV-RELATED PULMONARY ARTERIAL HYPERTENSION | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 1784 N DECATUR RD,S 530 NDBLDG | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| ATLANTA | GA | 30322-1048 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 1670 CLAIRMONT ROAD, 151-P | Recipient responsible for this data | DECATUR |
| State | Zip Code+4 | Congressional District |
| GA | 300033400 | 4 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
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USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
