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HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

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Award Detail for: GENES REGULATING NEUROGENESIS IN THE TRIGEMINAL PLACODE
BRIGHAM YOUNG UNIVERSITY
DUNS Number: 009094012
D-177 ASB
PROVO, UT 84602
Recipient Report: Grant or Loan
Prime Recipient

Reporting Information
Award Type Award Number Final Report
Grant 3R01HD046475-05S1 Recipient responsible for this data

Award Recipient Information
Recipient DUNS Number Recipient Account Number Recipient Congressional District
009094012 Recipient responsible for this data 3

Award Information
Funding Agency Code Awarding Agency Code Award Date
7529 7529 06-23-2009
Amount of Award Sub Account Number for Program Source (TAS)  
$ 12,485 Recipient responsible for this data
Program Source (TAS)* CFDA Number 
750845 93.701
Total Number of Sub Awards to Individuals Total Amount of Sub Awards to Individuals
Recipient responsible for this data Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award Total Amount of Payments to Vendors less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award Total Amount of Sub Awards less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Award Description
DESCRIPTION (provided by applicant): Trigeminal ganglion development is a well studied model of vertebrate neurogenesis, where neural crest and placode cells come together to form this group of sensory neurons. Several genes are known to be expressed in cells contributing to the ganglion, but the function of most has not been elucidated. This proposal aims to characterize the function of key gene products expressed during the early stages of trigeminal placode and ganglion development. Research proposed here will focus on two genes expressed in neurogenic placode cells: Pax-3 and FGFR4. Early in their development, placode cells express Pax-3 as they become committed. FGFR4 expression peaks during placode cell delamination. Several other genes are subsequently expressed in the trigeminal placode, including Brn3a, neurogenin-2, and other downstream neuronal markers. A model is proposed whereby these genes govern the stepwise process of placode development. The specific aims for this research are 1) determine the function of Pax-3 in trigeminal placode cell development, and 2) determine the function of FGFR4 in trigeminal placode cell development. Pax-3 and FGFR4 have been well studied in other embryonic model systems, providing a solid basis for experimental design. The results obtained from this research will be especially useful to neuroscientists, developmental and cancer biologist. The methods and experiments outlined in this proposal are based on extensive research showing that misexpression of genes in cells, tissues and live embryos is an effective approach to understanding cellular gene function. Preliminary data show the development and testing of misexpression and inhibitory constructs for these genes, which will be used in the chick embryo model system to fulfill the specific objectives. Proven techniques of gene misexpression will be utilized in this study, including RCAS retroviral mediated gene delivery and in ovo electroporation. The development of new reagents aimed at blocking gene expression including siRNA and morpholino technology have been successfully tested in our lab. Inhibition and misexpression experiments will be analyzed for cellular delamination, migration and proliferation, differentiation potential, and the expression of other important developmental genes. Important advances in our understanding of neuronal cell differentiation in development will be sought.

Project Information
Project Name or
Project/Program Title
Project Status Total Federal Amount ARRA Funds
Received/Invoiced
GENES REGULATING NEUROGENESIS IN THE TRIGEMINAL PLACODE Recipient responsible for this data Recipient responsible for this data
Number of Jobs Description of Jobs Created
Recipient responsible for this data Recipient responsible for this data
Quarterly Activities/Project Description
Recipient responsible for this data
 
Activity Code (NAICS or NTEE-NPC)
1Recipient responsible for this data2Recipient responsible for this data
3Recipient responsible for this data4Recipient responsible for this data
5Recipient responsible for this data6Recipient responsible for this data
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Total Federal Amount of ARRA
Expenditure
Total Federal ARRA
Infrastructure Expenditure
Infrastructure Contact Name
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Email Infrastructure Contact Phone Infrastructure Contact Phone Ext.
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Street Address 1 Infrastructure Contact Street Address 2 Infrastructure Contact Street Address 3
D-177 ASB Not Available Recipient responsible for this data
Infrastructure City Infrastructure State Infrastructure ZIP Code+4
PROVO UT 84602
Infrastructure Purpose and Rationale
Recipient responsible for this data

Primary Place of Performance
Street Address 1 Street Address 2 City
OFFICE OF RESEARCH & CREATIVE ACTIVITIESA-285 ASB Recipient responsible for this data PROVO
State Zip Code+4 Congressional District
UT 846021231 Not Available
Country  
US

Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability # Officer Name Officer Compensation
Recipient responsible for this data 1 Recipient responsible for this data Recipient responsible for this data
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The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.