HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 3R01CA080946-10S1 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 030811269 | Recipient responsible for this data | 8 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 09-22-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 311,587 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750850 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Selenium is an essential trace element in the diets of mammals because of its presence in selenocysteine- containing proteins. Clinical trials and animal studies have demonstrated the potent cancer prevention activity of selenium; however, mechanisms by which it decreases cancer incidence are not understood. This deficiency precludes identification of subsets of the human population that benefit from dietary selenium supplementation, as well as those who do not. At optimal concentrations of selenium in the diet, selenoproteins account for the major pool of this trace element in mammalian organs and tissues. Functionally characterized selenoproteins exhibit redox activities, and imbalance in the levels of these proteins affects redox homeostasis. The PI recently identified a full set of selenoproteins in mammals, many of which are redox proteins. Among them, the 15 kDa selenoprotein (Sep15) emerged as the major candidate for mediating the cancer prevention effect of dietary Se. In the previous funding cycle, the PI's research team carried out initial functional and structural characterization of Sep15, its homologs and interacting partners, and developed Sep15 mouse models. The role of selenoproteins and selenocompounds in the development of hepatic tumors in mice was also addressed. The research team is now poised to benefit from this foundation and proposes to characterize in detail the functions of Sep15 and members of its protein family and to use novel mouse models of hepatic selenoprotein deficiency to directly determine the role of selenoproteins in cancer prevention. This work will be guided by three questions (specific aims): 1) What is the role of Sep15 in oxidative protein folding? 2) What is the biological function of Sep15? and 3) What roles do selenoproteins play in cancer prevention? These questions will be addressed using a combination of biochemical and cell biology studies and animal models. Relevance to the public health: The trace element selenium protects against prostate, colon, lung, and liver cancer, but the mechanism of this effect and forms of selenium that contribute most to this protection are unknown. This research will examine selenoproteins implicated in cancer prevention and the factors affecting their functions. This research may have direct implications for human studies and may lead to the ability to identify segments of the human population at risk of developing cancers that can be prevented by selenium. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| SELENOPROTEINS AS TARGETS FOR CANCER PREVENTION | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 10 VINING STREET | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| BOSTON | MA | 02115-6114 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| HARVARD NEW RESEARCH BUILDING 4TH FLOOR 75 FRANCIS ST | Recipient responsible for this data | BOSTON |
| State | Zip Code+4 | Congressional District |
| MA | 02115 | 8 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
