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HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please contact our help desk at 866-814-5703.

 

Award Detail for: SELENOPROTEINS AS TARGETS FOR CANCER PREVENTION
BRIGHAM & WOMEN`S HOSPITAL
DUNS Number: 030811269
10 VINING STREET
BOSTON, MA 02115-6114
Recipient Report: Grant or Loan
Prime Recipient

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Reporting Information
Award Type Award Number Final Report
Grant 3R01CA080946-10S1 Recipient responsible for this data

Award Recipient Information
Recipient DUNS Number Recipient Account Number Recipient Congressional District
030811269 Recipient responsible for this data 8

Award Information
Funding Agency Code Awarding Agency Code Award Date
7529 7529 09-22-2009
Amount of Award Sub Account Number for Program Source (TAS)  
$ 311,587 Recipient responsible for this data
Program Source (TAS)* CFDA Number 
750850 93.701
Total Number of Sub Awards to Individuals Total Amount of Sub Awards to Individuals
Recipient responsible for this data Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award Total Amount of Payments to Vendors less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award Total Amount of Sub Awards less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Award Description
DESCRIPTION (provided by applicant): Selenium (Se) is an essential trace element in human nutrition due to its presence, in the form of selenocysteine residue, in 25 selenoproteins. Selenoproteins participate in diverse biological processes, but their key roles are to regulate cellular redox homeostasis. These redox activities are modulated by the level and chemical form of dietary Se in a selenoprotein- and organ-specific manner. Selenoprotein status has been implicated in a variety of physiological processes and diseases, but the function of Se that attracted the most attention is its role in cancer. There are numerous studies, including clinical trials, which support the role of Se in cancer prevention, but there are also studies that found no such role. The consensus is that Se may be beneficial under conditions of low Se status, when selenoprotein levels are suboptimal, whereas this micronutrient is not effective in cancer prevention when Se levels are above that needed to saturate selenoprotein expression. Our research revealed a dual role the 15 kDa selenoprotein (Sep15) in cancer. We hypothesize that Sep15 and its homolog selenoprotein M (SelM) serve as redox gatekeepers for disulfide-rich proteins that pass through the endoplasmic reticulum. This hypothesis will be addressed using cell culture and mouse models. We will determine redox targets of Sep15 and SelM, characterize consequences of their deficiency, profile immunoglobulins in selenoprotein knockout mice and examine their maturation status. In addition, we found that high-throughput analyses of selenoproteins in a large panel of human cancer cell lines provides direct insights into the functions of these proteins in the context of human cancer, control of redox homeostasis and dependence of various cancer types on selenoproteins. We will characterize the human selenoproteome and selenocysteine machinery for their roles in human cancer by analyzing coexpression patterns and dependence of various cancer types on selenoproteins and drugs, and will link this information with genotype and expression patterns. This information will define the roles of selenoproteins in human cancer and provide critical information for the development of approaches for personalized use of dietary selenium to modulate cancer prevention and progression. Overall, these studies will provide critical insights into the role of selenium and selenoproteins in cancer.

Project Information
Project Name or
Project/Program Title
Project Status Total Federal Amount ARRA Funds
Received/Invoiced
SELENOPROTEINS AS TARGETS FOR CANCER PREVENTION Recipient responsible for this data Recipient responsible for this data
Number of Jobs Description of Jobs Created
Recipient responsible for this data Recipient responsible for this data
Quarterly Activities/Project Description
Recipient responsible for this data
 
Activity Code (NAICS or NTEE-NPC)
1Recipient responsible for this data2Recipient responsible for this data
3Recipient responsible for this data4Recipient responsible for this data
5Recipient responsible for this data6Recipient responsible for this data
7Recipient responsible for this data8Recipient responsible for this data
9Recipient responsible for this data10Recipient responsible for this data
Total Federal Amount of ARRA
Expenditure
Total Federal ARRA
Infrastructure Expenditure
Infrastructure Contact Name
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Email Infrastructure Contact Phone Infrastructure Contact Phone Ext.
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Street Address 1 Infrastructure Contact Street Address 2 Infrastructure Contact Street Address 3
10 VINING STREET Not Available Recipient responsible for this data
Infrastructure City Infrastructure State Infrastructure ZIP Code+4
BOSTON MA 02115-6114
Infrastructure Purpose and Rationale
Recipient responsible for this data

Primary Place of Performance
Street Address 1 Street Address 2 City
77 AVE. LOUIS PASTEUR NRB ROOM 435 Recipient responsible for this data BOSTON
State Zip Code+4 Congressional District
MA 021155727 8
Country  
US

Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability # Officer Name Officer Compensation
Recipient responsible for this data 1 Recipient responsible for this data Recipient responsible for this data
2 Recipient responsible for this data Recipient responsible for this data
3 Recipient responsible for this data Recipient responsible for this data
4 Recipient responsible for this data Recipient responsible for this data
5 Recipient responsible for this data Recipient responsible for this data

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The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.