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HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.

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Award Detail for: EXERCISE DOSE AND NONALCOHOLIC FATTY LIVER DISEASE
SOUTHERN ILLINOIS UNIVERSITY AT EDWARDSVILLE
DUNS Number: 006331342
CAMPUS BOX 1007
EDWARDSVILLE, IL 62026
Recipient Report: Grant or Loan
Prime Recipient

Reporting Information
Award Type Award Number Final Report
Grant 3K01DK078738-04S1 Recipient responsible for this data

Award Recipient Information
Recipient DUNS Number Recipient Account Number Recipient Congressional District
006331342 Recipient responsible for this data 19

Award Information
Funding Agency Code Awarding Agency Code Award Date
7529 7529 07-16-2009
Amount of Award Sub Account Number for Program Source (TAS)  
$ 49,263 Recipient responsible for this data
Program Source (TAS)* CFDA Number 
750883 93.701
Total Number of Sub Awards to Individuals Total Amount of Sub Awards to Individuals
Recipient responsible for this data Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award Total Amount of Payments to Vendors less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award Total Amount of Sub Awards less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Award Description
DESCRIPTION (provided by applicant): This K01 application proposes an integrated research and training plan to develop expertise in exercise and cellular metabolism in subjects with nonalcoholic fatty liver disease (NAFLD). NAFLD affects -20% of adults in the United States and is associated with insulin resistance and the metabolic syndrome. Decreasing calorie intake and increasing physical activity have been recommended as primary therapy for NAFLD, but the independent effect of aerobic exercise is unknown. The current exercise guidelines for disease prevention and weight management range from 150 min/wk, recommended by the Centers for Disease Control and the American College of Sports Medicine, to 300 min/wk, recommended by the Institute of Medicine. However, it is not known whether aerobic exercise alone can improve NAFLD, and which recommended dose of exercise might have the most beneficial effects. The purpose of this proposal is to determine the effect of two levels of aerobic exercise on the following specific aims: 1) hepatic fat content; 2) hepatic lipoprotein kinetics; 3) insulin sensitivity; and 4) potential cellular mechanism that regulate insulin action. We hypothesize that aerobic exercise will decrease hepatic fat content, improve hepatic, skeletal muscle, and adipose tissue insulin sensitivity in a dose-dependent fashion. This proposal involves conducting a randomized controlled trial that will randomize 30 obese subjects with NAFLD (>10% hepatic fat content) to one of three groups for four months: Group 1 (Control, no exercise), Group 2 (Low-Dose Aerobic Exercise, 150 min/wk of supervised exercise performed at 45-55% of V02max (brisk walking)), and Group 3 (Moderate-Dose Aerobic Exercise, 300min/wk of supervised exercise performed at 45-55% of V02max). These hypotheses will be tested using: 1) magnetic resonance spectroscopy (MRS) to assess intrahepatic lipid content, 2) infusion of stable isotope tracers to measure hepatic VLDL-TG and VLDL-apoB secretion rates, 3) a two-stage euglycemic hyperinsulinemic clamp procedure to measure both hepatic, adipose tissue and skeletal muscle insulin sensitivity, 4) immunohistochemistry to determine content and localization of metabolic variables in muscle and fat. The relavance [sic] of this investigation to public health is it will help determine exercise guidelines for obese patients with NAFLD, and lay the groundwork for future studies evaluating the effects of exercise on metabolic diseases associated with obesity.

Project Information
Project Name or
Project/Program Title
Project Status Total Federal Amount ARRA Funds
Received/Invoiced
EXERCISE DOSE AND NONALCOHOLIC FATTY LIVER DISEASE Recipient responsible for this data Recipient responsible for this data
Number of Jobs Description of Jobs Created
Recipient responsible for this data Recipient responsible for this data
Quarterly Activities/Project Description
Recipient responsible for this data
 
Activity Code (NAICS or NTEE-NPC)
1Recipient responsible for this data2Recipient responsible for this data
3Recipient responsible for this data4Recipient responsible for this data
5Recipient responsible for this data6Recipient responsible for this data
7Recipient responsible for this data8Recipient responsible for this data
9Recipient responsible for this data10Recipient responsible for this data
Total Federal Amount of ARRA
Expenditure
Total Federal ARRA
Infrastructure Expenditure
Infrastructure Contact Name
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Email Infrastructure Contact Phone Infrastructure Contact Phone Ext.
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Street Address 1 Infrastructure Contact Street Address 2 Infrastructure Contact Street Address 3
CAMPUS BOX 1007 Not Available Recipient responsible for this data
Infrastructure City Infrastructure State Infrastructure ZIP Code+4
EDWARDSVILLE IL 62026
Infrastructure Purpose and Rationale
Recipient responsible for this data

Primary Place of Performance
Street Address 1 Street Address 2 City
OFFICE OF RESEARCH AND PROJECTSRESEARCH AND PROJECTS FISCAL MANAGEMENT Recipient responsible for this data EDWARDSVILLE
State Zip Code+4 Congressional District
IL 62026 19
Country  
US

Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability # Officer Name Officer Compensation
Recipient responsible for this data 1 Recipient responsible for this data Recipient responsible for this data
2 Recipient responsible for this data Recipient responsible for this data
3 Recipient responsible for this data Recipient responsible for this data
4 Recipient responsible for this data Recipient responsible for this data
5 Recipient responsible for this data Recipient responsible for this data

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The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.