HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 2R56DK072071-05 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 613338789 | Recipient responsible for this data | 8 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 04-12-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 222,300 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750883 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| Animal models have provided insight into the physiology of weight regulation, including the hormonal and neurological communication between adipose tissue, the gut, and the brain. Adipocyte hormones, such as leptin, and gut hormones, such as ghrelin, control meal-related food intake and energy expenditure through mechanisms that include direct binding to receptors in the brain stem and brain, and by altering afferent vagal signaling. Recent imaging studies in humans recording brain responses to visual and gustatory food stimuli have consistently demonstrated involvement of dopaminergic pathways traditionally linked with reward motivation. With the discovery of leptin receptors within these pathways, a more integrated model of central nervous system control of food intake is emerging. Most of the imaging reports to date, however, have been cross-sectional studies that have compared obese to lean subjects. Only a few have measured brain responses to changes in levels of hormones involved in weight regulation, such as leptin, and only one studied patients after weight loss. Because of counter regulatory hormonal control, sustained weight loss is difficult to achieve in obese subjects despite intensive behavioral strategies. Bariatric surgery, however, achieves meaningful sustained weight loss, but the mechanisms for this are poorly understood. Thus, the overall goal for this project is to bring together clinical scientists with expertise in brain imaging and the physiological and behavioral control of food intake to better understand the role and interaction of changes in the sensitivity of the brain to hormonal signaling and response to external food stimuli following bariatric surgery. Subjects about to undergo either gastric bypass, gastric banding, or a low-calorie diet weight loss program will complete fMRI paradigms assessing BOLD activation of brain reward circuitry in response to food intake and food images under three different infusion conditions: leptin, ghrelin, and saline. They will also complete measures of body composition, visual analog scores for hunger and satiety, and adlibitum food intake. Participants will then return two more times after surgery to repeat this assessment protocol to determine if these bariatric procedures differentially impact BOLD response of reward circuitry to hormonal and food stimuli and whether this responsivity predicts subsequent weight loss. Finally, subgroups with polymorphisms of the dopamine D2 receptor and those with persistent binge eating behavior are hypothesized to be less responsive to effects of hormonal manipulation on brain fMRI response, to surgically induced weight loss, and will be more likely to regain weight during long-term follow-up. This project will provide new insights into mechanisms leading to sustained weight loss that involve brain centers regulating body weight and attempt to identify subgroups that are responders or non-responders following bariatric surgery. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| G PROTEIN SIGNALING IN OSTEOBLASTS | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 4150 CLEMENT STREET | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| SAN FRANCISCO | CA | 94121-1545 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 4150 CLEMENT STREETBUILDING 6, 3RD FLOOR | Recipient responsible for this data | SAN FRANCISCO |
| State | Zip Code+4 | Congressional District |
| CA | 94121 | Not Available |
| Country | ||
| Not Available | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
