HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 2R01HL055417-14 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 555917996 | Recipient responsible for this data | 5 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 09-09-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 377,500 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750871 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Natural killer (NK) cells develop from primitive hematopoetic stem cells into functional anti-tumor effector cells that express receptors recognizing MHC class I ligands. In addition to the killer immunoglobulin-like receptor (KIR) family, NKG2A and LIR-1 also recognize MHC class I ligands. Our data show that although the population of KIR-/NKG2A- NK cells circulating in blood cannot be inhibited by self ligands, they are not autoreactive, but instead are hyporesponsive and tolerant. The mechanism by which these hyporesponsive cells acquire function is dependent first on the acquisition of NK cell receptors and then on subsequent interactions with their MHC class I ligands. The process of NK cell education is also referred to as licensing, calibration or arming/disarming. NK cells that have been educated by exposure to cognate ligand exhibit higher function against ligand-negative targets, while uneducated NK cells remain hyporesponsive. The overarching hypothesis is that the process of human NK cell education is coordinated with NK cell development and is further modulated by activation-inflammatory signals and inhibitory receptor ligation. We propose that although NK cell education can precisely adjust the innate immune response, this mechanism may not be absolute and that it can be reversed by activation-inflammatory signals. Although interactions between KIR and KIR-ligand dominate the clinical literature, a population of KIR- NK cells in blood exhibit potent anti-tumor function, possibly because they have been educated through NKG2A or LIR-1. During the current funding, we established a mechanistic link between IL-15, known to activate NK cells, and the upregulation of c-Myc. C-Myc binds directly to a KIR promoter 1 Kb upstream of the conventional proximal promoter and leads to distal promoter transcription. We hypothesize that several additional factors play a role in NK cell education, including Notch, stromal, homeostatic and inflammatory activation signals (independent of specific NK cell receptors), and lastly, interaction with inhibitory receptors. Our developmental model with human cord blood stem cells is ideal because it recapitulates NK cell development but favors NK cell receptor negative hyporesponsive NK cells. Three specific aims are proposed: Specific Aim 1: NK cell commitment and acquisition of global function as a developmental event. Specific Aim 2: NK cell education after NK cell commitment. Specific Aim 3: Mechanisms of KIR acquisition. The significance of these studies is of high translational interest given our own work suggesting a role for NK cells in hematopoietic cell transplantation and as therapy for cancer. Understanding mechanisms of KIR transcription may ultimately allow us to manipulate NK cells with specificity. PUBLIC HEALTH RELEVANCE: PROJECT Natural killer (NK) cells are a type of circulating white blood cell which can kill cancer cells and virally infected targets. As these innate immune cells develop from hematopoietic stem cells they develop the ability to kill targets and secrete cytokines. In order to induce self tolerance and avoid damage to healthy tissues, NK cells are educated by "self" MHC molecules which bind inhibitory NK receptors. The main goal of this R01 renewal is to understand the stages of NK cell development, including the acquisition of NK cell receptors, and the regulation of NK cell function. A thorough understanding of these mechanisms may allow us to manipulate NK cells for therapeutic purposes to treat cancer. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
||||||||||||||||||||||||
| NK CELL DIFFERENTIATION FROM STEM CELLS | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
|
||||||||||||||||||||||||||
| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 106 PLEASANT SE, 210 FRASER HL | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| MINNEAPOLIS | MN | 55455 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| MASONIC CANCER CENTER420 DELAWARE STREET SE | Recipient responsible for this data | MINNEAPOLIS |
| State | Zip Code+4 | Congressional District |
| MN | 55455 | 5 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
