HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 1RC1AG035870-01 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 555917996 | Recipient responsible for this data | 5 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 09-22-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 369,833 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750845 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): The central focus of this proposal explores how to fill a technological gap - the detection of specific A¿ oligomers in living subjects. The development of new techniques for measuring specific A¿ oligomers in living individuals will enable us to investigate how long individuals that are producing A¿*56, A¿ dimers and A¿ trimers may live before clinically recognizable signs of AD emerge. This project may improve both our understanding of the processes that initiate AD and our ability to diagnose it in its earliest stages, by determining whether specific A¿ oligomers appear early enough in AD to become a target for therapies aimed at preventing the illness altogether. If successful, the work could benefit millions of people in America and the world. Recently, in collaboration with researchers at Rush University, we found that A¿*56 levels were elevated in many elderly individuals with no cognitive impairment who, presumably, would have developed AD had they lived longer. We also showed that distinct A¿ oligomers were elevated in different phases of the development and progression of AD. Other researchers have missed these intricate patterns in the rise and fall of distinct A¿ oligomers, because they used tests which measure A¿ oligomers in bulk, without distinguishing between distinct species. One test of our hypothesis, that A¿*56 initiates AD, is to observe the long-term consequences of A¿*56 in the brain. However, since we cannot monitor A¿*56 in the brains of living subjects, we will instead measure A¿*56 in readily accessible test specimens, preferably blood, but also spinal fluid. Using our current immunoblotting methods we can detect A¿*56 in brain and spinal fluid, but not in blood. This suggests that the levels of A¿*56 in blood are extremely low, or absent. However, there is indirect evidence in APP transgenic mice that A¿*56 is present in the blood. In the past few years, researchers in the laboratory of Dr. Srinand Sreevatsan developed DNA aptamers capable of detecting the scrapie isoform of the prion protein in the blood of scrapie-infected sheep, at levels far below the detection threshold of immunoblotting methods. Lately, researchers at the Mayo Clinic led by Dr. Ronald Petersen completed enrollment of nearly 2,000 elderly residents of Rochester, Minnesota, in a longitudinal study of genetic, biomarker, and imaging aspects of aging and very early cognitive problems, and have agreed to make spinal fluid and blood samples available to us. In this Challenge grant application, we propose to collaborate with Dr. Sreevatsan to develop DNA aptamers which detect specific A¿ oligomers, and to use these aptamers to measure distinct A¿ oligomers, including A¿*56, in the spinal fluid and blood of the Mayo Clinic cohort. PUBLIC HEALTH RELEVANCE: The central focus of this proposal explores how to fill a technological gap - the detection of specific A¿ oligomers in living subjects. The development of new techniques for measuring specific A¿ oligomers in living individuals will enable us to investigate how long individuals that are producing A¿*56, A¿ dimers and A¿ trimers may live before clinically recognizable signs of AD emerge. This project may improve both our understanding of the processes that initiate AD and our ability to diagnose it in its earliest stages, by determining whether specific A¿ oligomers appear early enough in AD to become a target for therapies aimed at preventing the illness altogether. If successful, the work could benefit millions of people in America and the world. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| SPECIFIC AMYLOID-BETA OLIGOMER APTAMERS | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 106 PLEASANT SE, 210 FRASER HL | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| MINNEAPOLIS | MN | 55455 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 2101 6TH ST SE | Recipient responsible for this data | MINNEAPOLIS |
| State | Zip Code+4 | Congressional District |
| MN | 55455 | 5 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
