HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 1R21NS065357-01 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 872612445 | Recipient responsible for this data | 22 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 05-01-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 210,430 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750901 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Clinical evidence suggests a strong link between Alzheimer's disease (AD) and cerebral microvascular dysfunction, but it remains unclear whether they contribute independently to dementia, or if AD pathology triggers microvascular disease, or vice versa. In AD, amyloid-¿ (A¿) peptides aggregate to form neurotoxic oligomers and eventually accumulate as amyloid plaques. Aggregation of A¿ depends on concentration, so events that increase production or decrease clearance of A¿ could be triggers for AD. A major pathway for the removal of A¿ from the brain is through the vasculature, suggesting that microvascular lesions could interfere with A¿ clearance. In addition, vascular lesions can lead to increased reactive oxygen species and to inflammation, which are linked to A¿ increase. We recently developed optical methods to create lesions in individual, specifically-targeted microvessels in rodent cortex. We now propose to test the hypothesis that microvascular lesions initiate or accelerate A¿ accumulation and amyloid plaque formation. To perform these studies, femtosecond laser irradiation will be used to injure a specifically targeted blood vessel, causing the formation of a microhemorrhage and/or of a clot that stops blood flow. We will produce microvascular clots and hemorrhages in individual cortical penetrating arterioles and capillaries in transgenic AD mice that express amyloid precursor protein (Mo/HuAPP695swe) and mutant presenilin1 (PS1-dE9), as well as in age-matched controls. Amyloid plaques will be labeled in vivo with systemic injections of methoxy-X04, a Congo-red derivative. The location of the lesions will be imaged daily over several days with two-photon excited fluorescence microscopy to determine the persistence of the occlusion or hemorrhage and the presence of previously existing and new amyloid plaques. Post-mortem labeling with thioflavin-S and A¿ antibodies will be used to further elucidate the impact of the microvascular lesion on A¿ accumulation and amyloid plaque formation. In Aim 1, we test whether microvascular clots and hemorrhages trigger rapid amyloid plaque formation for lesions at different locations in the vascular tree, and where amyloid plaques form relative to the lesion site. In Aim 2, we determine the time required for amyloid plaques to form following microvascular lesions and whether amyloid plaques that are initiated by microvascular lesions are stable over time. In the final Aim, we investigate how the age of the animal, or the pre-existing plaque burden, influences the seeding of amyloid plaques by microvascular lesions. In preliminary work, we found that microvascular clots led to the formation of new amyloid plaques within one day (3/3 clots in 3 animals, see Fig. 7). New plaques were formed both on the clotted microvessel and in the nearby parenchymal tissue. Nearby vessels of similar diameter that were not lesioned showed no new amyloid plaques. These initial results indicate that a severe decrease in blood flow resulting from the occlusion of a single microvessel can trigger amyloid plaque formation. These data suggest that microvascular clots could play an important role in Alzheimer's disease pathogenesis. PUBLIC HEALTH RELEVANCE: Alzheimer's disease (AD) is the leading cause of dementia in the elderly and although some recent treatments modestly slow progression of disease, there is no cure. Clinical research has shown that vascular health is an important factor in the severity of AD in patients, yet the mechanisms that link vascular dysfunction and AD remain unclear. This work uses a unique combination of optical and biological tools to directly study how microvascular clots and hemorrhages in the brain affect the development of AD and our preliminary results show that microvascular dysfunction may play a role in initiating AD, suggesting that successful AD prevention will depend on treatment of vascular disease. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| ROLE OF CORTICAL MICROVASCULAR LESIONS IN AMYLOID-BETA ACCUMULATION | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 373 PINE ROAD | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| ITHACA | NY | 14850 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| OFFICE OF SPONSORED PROGRAMS | Recipient responsible for this data | ITHACA |
| State | Zip Code+4 | Congressional District |
| NY | 148502820 | 22 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
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USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
