HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 1R21DK075857-01A2 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 071723621 | Recipient responsible for this data | 8 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 07-16-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 212,500 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750883 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Patients with chronic liver disease frequently progress to fibrosis and finally cirrhosis. Cirrhosis is the most important determinant of liver-related mortality. At present there exists no proven therapy to halt fibrosis progression or to reverse cirrhosis. Activated hepatic stellate cells and myofibroblasts (collectively termed HSC) produce most of the scar tissue in liver fibrosis and thus drive fibrogenesis. During early activation the same cells also express the enzymes that dissolve scar components, such as certain matrix metalloproteinases (MMPs). While fibrogenic activation of HSC is fairly well defined, their potential to dissolve scar tissue, i.e., to induce fibrolysis, is largely unexplored. We have shown that 1) cell membrane derived microparticles (MP) from apoptotic or activated T cells but not from hepatocytes induce the expression of fibrolytic MMPs in HSC; 2) these MP fuse with HSC cell membranes; 3) fibrolytic gene expression is triggered via activation of Erk1/2, nuclear factor kappa B (NFkB) and p38 kinase l; and 4) MP contain membrane molecules that are likely candidates of HSC fibrolytic activation. The central hypothesis of this proposal is that MP released from T-cells can induce a fibrolytic phenotype in HSC, potentially reversing liver fibrosis and cirrhosis. Our goals are 1) to identify T cell subsets that generate the most effective fibrolytic MP, and 2) to identify the molecules and signal transduction pathways by which MP induce fibrolytic genes. Aim 1 will study the effect of MP released from activated T-cell subpopulations on the fibrogenic/fibrolytic phenotype of HSC. T cells will be CD4+, CD8+, CD25+, and Th1 or Th2 T- polarized. Aim 2 will identify the molecules and examine the signal transduction pathways that lead to acquisition of a fibrolytic phenotype by HSC exposed to MP. Our proposed studies will provide information on the contribution of MP to fibrolytic activation of HSC, and their potential role in favorable architectural remodeling of the fibrotic liver. The information gained will also impact on the understanding of fibrolysis in other organ pathologies which have chronic inflammation as a common feature. Our long-term goal is to explore novel MP-based strategies to treat advanced hepatic fibrosis. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| FIBROLYTIC ACTIVATION OF HEPATIC STELLATE CELLS BY T CELL DERIVED MICROPARTICLES | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 330 BROOKLINE AVENUE | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| BOSTON | MA | 02215-5400 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| DA 501330 BROOKLINE AVE. | Recipient responsible for this data | BOSTON |
| State | Zip Code+4 | Congressional District |
| MA | 2215 | Not Available |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
