HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 1R21AI083538-01 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 068552207 | Recipient responsible for this data | 1 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 07-17-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 224,848 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750900 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Dendritic cells (DCs) are potent antigen presenting cells that play an essential role initiating and guiding immune responses toward intestinal pathogens and non-pathogens. Recent studies using microscopy techniques demonstrated that the intestine contains a population of DCs that are uniquely positioned at the interface of the host with the environment. These DCs extend dendrites into the intestinal lumen to sample and respond to stimuli and because of their physical location these DCs have great potential to influence immune responses. Despite these seminal observations, studies directly assessing this DC population are lacking. The function of these cells is largely inferred from studies of related DC populations, and from studies of in vitro derived DCs treated with epithelial cell conditioned media. Furthermore the phenotypic diversity of this DC population is almost completely unexplored. In this proposal we will define the phenotypic and functional diversity of epithelium associated dendritic cells (EA-DC) from the mouse and human small intestine. The overarching hypothesis of this proposal is that intestinal EA-DC include two subtypes of DCs with dichotomous phenotypes and functions, inflammatory DCs and tolerogenic DCs. These DCs migrate from the lamina propria (LP) to become closely associated with the epithelium in response to pathogenic or non- pathogenic signals respectively, sample lumenal stimuli, including dietary vitamin A, and subsequently migrate to mesenteric lymph nodes (MLN) to initiate vitamin A dependent mucosal adaptive immune responses. In specific aim 1 we will define the phenotypic and functional diversity of the murine and human EA-DC population. These studies will evaluate this population of cells with flow cytometry to define the EA-DC subtypes and examine these cells for the expression of toll like receptors and chemokine receptors. The morphology of these EA-DC subtypes will be evaluated with electron microscopy. The function of these DC subtypes will be investigated by evaluating the ability of these cells to imprint gut homing of lymphocytes, induce IgA class switch, and stimulate and differentiate T-lymphocytes. The physical location of the EA-DC subtypes will be evaluated in models of non-pathogenic and pathogenic infections. In specific aim 2 we will define the role of dietary vitamin A in establishing the EA-DC niche and in EA-DC function by evaluating the EA-DC subtypes for the expression of specialized molecular machinery for the uptake and storage of dietary vitamin A. We will evaluate the role of dietary source of vitamin A for mucosal specific functions of the EA-DC, and we will evaluate a role for dietary vitamin A in altering DC phenotype to occupy the EA niche. Dendritic cells are the most powerful immune cells for starting and guiding the character of immune responses, thus these cells play important roles in defending against infections and in preventing unwanted harmful immune responses. The intestine contains unique populations of dendritic cells that we know very little about. This study will increase our knowledge about how these dendritic cells work to protect us from intestinal infections and prevent unwanted harmful immune responses. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| EPITHELIA ASSOCIATED DENDRITIC CELLS: PHENOTYPE AND FUNCTION | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| CAMPUS BOX 1034 | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| SAINT LOUIS | MO | 63112 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 660 SOUTH EUCLID AVENUE | Recipient responsible for this data | ST. LOUIS |
| State | Zip Code+4 | Congressional District |
| MO | 63110 | 1 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
