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HHS Recovery Act Recipient Reporting Readiness Tool

Step 4. Review and Copy the Grant Awards Data

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Award Detail for: QUANTIZATION OF OCULAR OXYGEN USING A MODIFIED FLUOROTRON
NORTHERN ILLINOIS UNIVERSITY
DUNS Number: 001745512
201 Lowden Hall
DEKALB, IL 60115
Recipient Report: Grant or Loan
Prime Recipient

Reporting Information
Award Type Award Number Final Report
Grant 1R15EY020995-01 Recipient responsible for this data

Award Recipient Information
Recipient DUNS Number Recipient Account Number Recipient Congressional District
001745512 Recipient responsible for this data 14

Award Information
Funding Agency Code Awarding Agency Code Award Date
7529 7529 09-27-2010
Amount of Award Sub Account Number for Program Source (TAS)  
$ 350,455 Recipient responsible for this data
Program Source (TAS)* CFDA Number 
750902 93.701
Total Number of Sub Awards to Individuals Total Amount of Sub Awards to Individuals
Recipient responsible for this data Recipient responsible for this data
Total Number of Payments to Vendors less than $25,000/award Total Amount of Payments to Vendors less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Total Number of Sub Awards less than $25,000/award Total Amount of Sub Awards less than $25,000/award
Recipient responsible for this data Recipient responsible for this data
Award Description
DESCRIPTION (provided by applicant): The major goal of this proposal is to standardize the technique such that oxygen can be accurately quantified throughout the eye. This involves each of the main compartments within the eye, namely, the aqueous, lens and vitreous. In the process of these studies we will determine the viscosity of the lens, which is essential to determining the diffusion of oxygen and nutrients in that tissue. Oxygen levels are not only crucial to the health of different ocular tissues, but also changes in the concentration of oxygen are involved in the etiology of diseases such as cataract or AMD. It is, therefore, important to study oxygen levels in various positions and structures within the eye under normal and disease conditions. To date, the primary method of measuring oxygen is the utilization of physical probes such as oxygen electrodes or optodes. These have the disadvantage of damaging the eye itself or of the probes becoming damaged while being inserted into the eye. In conjunction with Bruce Ishimoto of Ocumetrics, we have modified a Fluorotron Ocular Fluorometer such that it can now detect phosphorescence from an oxygen sensitive palladium porphyrin (eg. PdUp palladium uroporphyrin). This instrument is capable of scanning through the entire eye and detecting oxygen throughout that tissue in a continuous manner. Using this instrument, we propose the following specific aims: I) To evaluate, characterize and quantify phosphorescence from various ocular structures using the Fluorotron. In conjunction with these studies, we will determine the viscosity of the lens, which is important in the diffusion of nutrients and oxygen within the lens. II) To apply this to a rabbit model. Again the values will be compared to those obtained using an optode, which is a method that we have successfully used before (see appendix 2). III) After a vitrectomy the vitreous is replaced by various solutions that are at atmospheric oxygen. In the course of these studies we will investigate the putative chemical processes involved in the reduction of oxygen tension in the vitreous and the levels of those anti-oxidants in human vitreal samples. The development of this technique will greatly expand our knowledge of the diffusion of oxygen throughout the eye and its possible role in the etiology of disease. PUBLIC HEALTH RELEVANCE: Oxygen levels are not only crucial to the health of different ocular tissues, but changes in the concentration of oxygen are also involved in the etiology of diseases such as cataract or AMD. It is, therefore, important to study oxygen levels in various positions and structures within the eye under normal and disease conditions. To date, this has been done primarily by means of physical probes that can either damage the eye itself or that can undergo damage themselves while being inserted into the eye. We propose to develop a noninvasive technique that will allow accurate quantification of oxygen throughout the eye. The development of this technique will greatly expand our knowledge of the diffusion of oxygen throughout the eye and its possible role in the etiology of disease, which has considerable implications for public health. These studies will eventually lead to the development of methods to control oxygen levels within the eye.

Project Information
Project Name or
Project/Program Title
Project Status Total Federal Amount ARRA Funds
Received/Invoiced
QUANTIZATION OF OCULAR OXYGEN USING A MODIFIED FLUOROTRON Recipient responsible for this data Recipient responsible for this data
Number of Jobs Description of Jobs Created
Recipient responsible for this data Recipient responsible for this data
Quarterly Activities/Project Description
Recipient responsible for this data
 
Activity Code (NAICS or NTEE-NPC)
1Recipient responsible for this data2Recipient responsible for this data
3Recipient responsible for this data4Recipient responsible for this data
5Recipient responsible for this data6Recipient responsible for this data
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Total Federal Amount of ARRA
Expenditure
Total Federal ARRA
Infrastructure Expenditure
Infrastructure Contact Name
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Email Infrastructure Contact Phone Infrastructure Contact Phone Ext.
Recipient responsible for this data Recipient responsible for this data Recipient responsible for this data
Infrastructure Contact Street Address 1 Infrastructure Contact Street Address 2 Infrastructure Contact Street Address 3
201 Lowden Hall Not Available Recipient responsible for this data
Infrastructure City Infrastructure State Infrastructure ZIP Code+4
DEKALB IL 60115
Infrastructure Purpose and Rationale
Recipient responsible for this data

Primary Place of Performance
Street Address 1 Street Address 2 City
Not Available Recipient responsible for this data DEKALB
State Zip Code+4 Congressional District
IL 601152864 Not Available
Country  
US

Recipient Highly Compensated Officers
Prime Recipient Indication of Reporting Applicability # Officer Name Officer Compensation
Recipient responsible for this data 1 Recipient responsible for this data Recipient responsible for this data
2 Recipient responsible for this data Recipient responsible for this data
3 Recipient responsible for this data Recipient responsible for this data
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