HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 1R03DE019191-01A1 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 030811269 | Recipient responsible for this data | 8 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 07-16-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 129,250 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750874 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Given the high incidence of bone trauma, cancer, and adult and congenital disease, which is associated with over 500,000 bone graft procedures each year in North America, it is not surprising that bone is the most common transplanted tissue, second only to blood. In addition to traditional bone grafting for defects, there are numerous clinical applications that can benefit from bone regeneration therapies including temporomandibular joint reconstruction to alleviate jaw pain which affects an estimated 90 million Americans, and restoration of contour and shape within reconstructed craniofacial bone. Mesenchymal stem and progenitor cells (MSPCs) are believed to play an important role during bone regeneration, however very little is known regarding their invasion into damaged or diseased tissue. To date there are no studies that examine the temporal and spatial distribution of endogenous mesenchymal stem and progenitor cells (MSPCs) during endosseous wound regeneration. Such characterization may be critical to developing therapeutic strategies that rely on recruitment of these cells (i.e., via delivery of growth factors) or the use of an exogenous source of stem or progenitor cells. Additionally, the impact of implanting or injecting scaffolds or hydrogel matrices on the migration and differentiation of MSPCs is unknown. Here we aim to characterize the spatial-temporal profile of endogenous MSPC migration and differentiation within defects that regenerate at different rates that will facilitate the creation of a core animal model for our laboratory. This will be used to interrogate various pathways involving MSPCs in regeneration of damaged or diseased bone tissue. AIM 1: To characterize the spatial and temporal aspects of MSPC migration and differentiation during endosseous wound healing within non-critical size defects. This will be accomplished through first validating antibodies in vitro with purified populations of MSPCs, followed by immunohistochemical analysis of MSPC migration and differentiation within a rat non-critical sized endosseous defect. AIM 2: To determine if the spatial-temporal migration and differentiation of endogenous MSPCs changes upon implantation of biomaterial matrices which significantly delay bone regeneration. Public Health Relevance: Existing clinical strategies for regeneration of craniofacial bone defects including functional deficits and severe aesthetic deformities are fraught with many limitations. We aim to characterize the spatial-temporal profile of endogenous mesenchymal stem and progenitor cell migration and differentiation within defects that regenerate at different rates. This will facilitate the creation of a core animal model that we can use to develop new strategies for enhancing bone regeneration based on harnessing the regenerative capacity of mesenchymal stem cells. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| CHARACTERIZATION OF ENDOGENOUS STEM CELLS WITHIN ENDOSSEOUS WOUNDS | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| 10 VINING STREET | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| BOSTON | MA | 02115-6114 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| RESEARCH ADMINISTRATION 75 FRANCIS ST | Recipient responsible for this data | BOSTON |
| State | Zip Code+4 | Congressional District |
| MA | 2115 | Not Available |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
