HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 1F31AG033452-01A1 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 068552207 | Recipient responsible for this data | 1 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 05-19-2009 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 41,176 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750842 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Alzheimer's Disease (AD) is the leading cause of late-onset dementia and is characterized by progressive cognitive decline and memory loss, ultimately leading to death. Over 5 million Americans are currently suffering from AD, and the total costs of AD and other dementias exceed $145 billion annually. Understanding the pathogenesis of AD in order to ultimately develop effective treatments is therefore paramount and is the motivation for this research proposal. Accumulation of the amyloid beta (AP) peptide into oligomeric forms and insoluble amyloid plaques appears to play a critical role in AD pathogenesis. Conversion of soluble Ab into these toxic species is concentration-dependent. Thus, mechanisms that regulate the amount of Ab in the brain may act as key determinants of whether A (3will aggregate into toxic forms. Data from our laboratory and others have demonstrated that synaptic activity regulates Ab levels within the extracellular space of the brain (interstitial fluid - ISF). However, how ISF Ab levels change as a result of physiological alterations in synaptic activity is not known. Therefore, the objective of this proposal is to determine the effect of physiological manipulations that alter synaptic activity on ISF Ab levels in vivo. I hypothesize that physiological changes in neuronal activity dynamically regulate the release of Ab into the extracellular space of the brain. In Specific Aim 1,1 will stimulate the whiskers of a live mouse in order to elicit an acute increase in neuronal activity within the barrel cortex. During the stimulation period, I will use electrophysiological recording simultaneously with in vivo microdialysis in barrel cortex to measure neuronal activity and ISF Ab levels and observe how levels change during whisker stimulation. In Specific Aim 2, I will determine the effect of voluntary exercise on ISF Ab levels and neuronal activity in hippocampus and primary motor cortex by performing in vivo microdialysis with concurrent electrophysiological recording in these brain regions during exercise. I will also examine the effect of exercise on APP processing by extracting brains after exercise and measuring protein levels of APP derivatives by Western blot. In Specific Aim 3,1 will determine the effects of environmental enrichment on ISF Ab levels and neuronal activity using in vivo microdialysis and electrophysiological recording in the hippocampus following enrichment. Finally, I will use microdialysis to determine if enrichment alters Ab clearance from the extracellular space of the brain. Public Health Relevance: The relevance of this proposal to public health is that elucidating the mechanisms that regulate Ab levels in the brain under normal physiological conditions may provide novel insights into AD pathogenesis and may ultimately provide new opportunities for therapeutic intervention. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| EFFECT OF PHYSIOLOGICAL CHANGES IN NEURONAL ACTIVITY AB LEVELS IN VIVO | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| CAMPUS BOX 1034 | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| SAINT LOUIS | MO | 63112 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| 660 S. EUCLID AVENUE | Recipient responsible for this data | SAINT LOUIS |
| State | Zip Code+4 | Congressional District |
| MO | 63110 | 3 |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
