HHS Recovery Act Recipient Reporting Readiness Tool
Step 4. Review and Copy the Grant Awards Data
TAGGS provides some – but not all – of the data needed for the Recipient Report. Recipients are responsible for directly collecting and reporting all required data to FederalReporting.gov. Data that HHS does not currently collect are highlighted in yellow. Do not copy this highlighted information. Please enter the appropriate data for your organization in these required fields. For assistance with entering these data please contact FederalReporting.gov.
You may capture the data HHS does provide by copying data from this screen and pasting it into the reporting format of your choice, such as the Excel spreadsheet template, the XML template, or by logging into the online form. For assistance with copying and pasting these data please e-mail our help desk at Readiness Help.
| Recipient Report: Grant or Loan | ||
| Prime Recipient |
| Reporting Information | ||
| Award Type | Award Number | Final Report |
| Grant | 5R21DK075868-02 | Recipient responsible for this data |
| Award Recipient Information | ||
| Recipient DUNS Number | Recipient Account Number | Recipient Congressional District |
| 063690705 | Recipient responsible for this data | 6 |
| Award Information | ||
| Funding Agency Code | Awarding Agency Code | Award Date |
| 7529 | 7529 | 08-12-2010 |
| Amount of Award | Sub Account Number for Program Source (TAS) | |
| $ 183,125 | Recipient responsible for this data | |
| Program Source (TAS)* | CFDA Number | |
| 750883 | 93.701 | |
| Total Number of Sub Awards to Individuals | Total Amount of Sub Awards to Individuals | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Payments to Vendors less than $25,000/award | Total Amount of Payments to Vendors less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Total Number of Sub Awards less than $25,000/award | Total Amount of Sub Awards less than $25,000/award | |
| Recipient responsible for this data | Recipient responsible for this data | |
| Award Description | ||
| DESCRIPTION (provided by applicant): Our ultimate goal is to develop a non-invasive procedure for the diagnosis of IgA nephropathy (IgAN). The specific goal of the studies proposed in this application is to identify urinary polypeptides that can be used as biomarkers of IgAN. In preliminary studies, we have demonstrated elevated levels of IgA and IgG immunoglobulins and IgA-IgG complexes in the urine of IgAN patients using immune complex-specific ELISA. Furthermore, we have identified several potential urinary polypeptide biomarkers for IgAN by capillary electrophoresis-mass spectrometry (CE-MS) and sequenced some of these polypeptides using tandem mass spectrometry. Based on these data, we hypothesize that the urine proteome of IgAN patients contains disease-specific biomarkers. We propose to test this hypothesis by first confirming our preliminary data through analysis of archival urine samples collected during studies of IgAN from well-characterized patients and controls. We will determine the levels of immunoglobulins and immune complexes using classical and immune complex-specific ELISA protocols with quality assurance and verification by western blot analysis. These data will then be extended by analysis using CE-MS to identify positive and negative biomarkers of disease in which the software tool, MosaCluster, with support vector machines, will be used for classification of samples. This approach will define a membership, with positive values (disease-associated marker) and negative values (marker for normal). The results of ELISA and CE-MS will be compared and correlated with the clinical findings. Candidate biomarkers identified by CE-MS will be further characterized by Fourier transform-ion cyclotron resonance MS to define the amino acid sequence and post- translational modifications. Finally, candidate biomarkers will be verified using an independent cohort of patients and controls. This study is designed to identify markers that can be used to distinguish IgAN from other renal diseases as well as biomarkers of disease progression and severity. Relevance: IgAN is the most common primary glomerulonephritis worldwide. Currently, diagnosis requires an invasive renal biopsy and IgAN is frequently diagnosed at a very late stage. The identification of biomarkers that can be used as the basis of a noninvasive diagnostic test and/or used to monitor the course of the disease would be extremely beneficial. | ||
| Project Information | ||||||||||||||||||||||||||
| Project Name or Project/Program Title |
Project Status | Total Federal Amount ARRA Funds Received/Invoiced |
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| URINARY POLYPEPTIDE BIOMARKERS OF IGA NEPHROPATHY | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Number of Jobs | Description of Jobs Created | |||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | |||||||||||||||||||||||||
| Quarterly Activities/Project Description | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
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| Total Federal Amount of ARRA Expenditure |
Total Federal ARRA Infrastructure Expenditure |
Infrastructure Contact Name | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Email | Infrastructure Contact Phone | Infrastructure Contact Phone Ext. | ||||||||||||||||||||||||
| Recipient responsible for this data | Recipient responsible for this data | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure Contact Street Address 1 | Infrastructure Contact Street Address 2 | Infrastructure Contact Street Address 3 | ||||||||||||||||||||||||
| UAB STATION, CBB 990 | Not Available | Recipient responsible for this data | ||||||||||||||||||||||||
| Infrastructure City | Infrastructure State | Infrastructure ZIP Code+4 | ||||||||||||||||||||||||
| BIRMINGHAM | AL | 35294 | ||||||||||||||||||||||||
| Infrastructure Purpose and Rationale | ||||||||||||||||||||||||||
| Recipient responsible for this data | ||||||||||||||||||||||||||
| Primary Place of Performance | ||
| Street Address 1 | Street Address 2 | City |
| Not Available | Recipient responsible for this data | BIRMINGHAM |
| State | Zip Code+4 | Congressional District |
| AL | 352942170 | Not Available |
| Country | ||
| US | ||
| Recipient Highly Compensated Officers | |||
| Prime Recipient Indication of Reporting Applicability | # | Officer Name | Officer Compensation |
| Recipient responsible for this data | 1 | Recipient responsible for this data | Recipient responsible for this data |
| 2 | Recipient responsible for this data | Recipient responsible for this data | |
| 3 | Recipient responsible for this data | Recipient responsible for this data | |
| 4 | Recipient responsible for this data | Recipient responsible for this data | |
| 5 | Recipient responsible for this data | Recipient responsible for this data | |
This concludes the current search.
To begin a new search, return to the HHS Recovery Act Recipient Reporting Readiness Tool.
USE IN THE RECIPIENT REPORT
The information provided by this tool is baseline data that the Recipient should include in the Recipient Report that must be submitted to FederalReporting.gov beginning October 1, 2009. The data from this tool can be cut and pasted directly into the Recipient Report.
