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Development of an Automated Diagnostic Platform for SARS-CoV-2 Monitoring in Vulnerable Areas

Award Number: U01AA029328
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The devastation caused by emerging pathogens with fast transmission capacity, such as SARS-CoV-2, has demonstrated the importance of preparedness for future viral outbreaks; this includes the ability for fast deployment of in-situ testing tools and epidemiological surveillance with high temporal and spatial resolution; particularly in places that are most vulnerable to becoming reservoirs of infectious agents. We propose to develop a versatile multiplexing detection platform for SARS-CoV-2 in saliva. The proposed system will integrate signals from different biorecognition elements. Aptamer, antibody, and ACE2 will be immobilized onto laser inscribed graphene electrodes, and detection mechanisms targeting SARS-CoV-2 spike protein will be studied under varying testing conditions (pH, temperature, ionic strength). After determining the operating conditions for enhanced performance of each biosensor, a self-referencing approach will be used between complementary recognition elements (i.e., possible combinations of aptamers, antibodies, and ACE2 enzyme biosensors) to evaluate the effects on test results accuracy (i.e., risk of false-positive and false-negative results). A saliva pre-treatment protocol will be developed to facilitate SARS-CoV-2 testing in human saliva using the multiplex biosensor platform. An open channel microfluidics system will be designed to automatically split and channel a single saliva sample into multiple streams to the biosensors without saturation, biofouling, and pump requirement. The development of a functional and reliable multiplex biosensor system will be useful for addressing longstanding needs in public health as the respiratory Coronavirus family continues its seasonal visits, which may repeat over several decades, much like the occasional visits from the influenza virus, with varying degrees of virulence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$395 )
2024	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	000	2	4/15/2024	EXTENSION WITH OR WITHOUT FUNDS	-$395
														Subtotal = -$395

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	000	2	12/27/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	001	1	6/20/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $426,004 )
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	000	2	12/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$426,004
2022	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	001	1	2/15/2022	NEW	$0
2022	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	002	1	5/31/2022	NEW	$0
														Subtotal = $426,004

Issue Date FY: 2021 ( Subtotal = $471,237 )
2021	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	001	1	2/15/2021	NEW	$0
2021	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Alcohol Research Programs	000	1	12/21/2020	NEW	$471,237
														Subtotal = $471,237

Grand Total All Awards = $896,846

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Development of an Automated Diagnostic Platform for SARS-CoV-2 Monitoring in Vulnerable Areas

Award Number: U01AA029328

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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