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Application of graph theory to both resting-state and task-based fMRI data to uncover brain-behavior relationships related to therapy outcomes in aphasia

Award Number: R21DC016708
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Although many treatment paradigms exist for aphasia rehabilitation with behaviorally successful outcomes, there is still much debate regarding the “best” pattern of neural reorganization during recovery. This lack of consensus may be due, in part, to incomplete exploration of the link between neural reorganization and behavior. The proposed project will apply graph theoretical measures to both task-based and resting-state fMRI (rs-fMRI) data to examine changes in functional connectivity related to treatment outcomes in persons with aphasia. Graph theory and rs-fMRI are currently underutilized in clinical aphasiology. Graph theory is gaining popularity in other areas of cognitive science as a meaningful technique for the characterization of brain network dynamics. Resting-state fMRI has been gaining popularity in other areas of clinical research as an easily acquired and informative measure of general cognitive functioning. Twenty participants with aphasia (PWA) will be scanned using fMRI at four time points. Between scan 1 and scan 2, no therapy will be provided, establishing a baseline control for each PWA. Between scan 2 and scan 3, ten weeks of word finding therapy will be provided. Between scan 3 and scan 4, no therapy will be provided, allowing for measurement of maintenance effects. The treatment used is abstract word retrieval training. This treatment was chosen because it has been shown to be not only successful at improving abstract word retrieval, but also improving retrieval of related concrete words that are not trained (i.e., generalization) (Kiran, Sandberg, & Abbott, 2009; Sandberg & Kiran, 2014). This makes the treatment more effective and a good candidate for promoting positive neural changes. Furthermore, abstract and concrete words have been shown to have differing neural activation patterns. This allows for the systematic examination of direct training and generalization effects of treatment on brain reorganization. For the graph theory analysis, regions of interest (ROIs) will be defined using a data-driven spatially-constrained approach developed by Drs. Hillary and Molenaar. Once correlations matrices are defined for each time point, graph theoretical measures will be calculated and compared at each time point to systematically examine changes in functional connectivity related to therapy outcomes. The methodological approach in this proposal is innovative in the use of two baseline scans before treatment and two maintenance scans after treatment and the application of graph theory and rs-fMRI to examine treatment-related brain reorganization in aphasia. The successful completion of this project is expected to help inform current theories of optimal reorganization patterns after stroke and provide groundwork for establishing informative and appropriate methods for measuring brain reorganization in aphasia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	000	3	5/18/2023	NON-COMPETING CONTINUATION	$0
2023	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	001	3	5/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	000	3	4/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $15,138 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	000	3	6/25/2021	SUPPLEMENT FOR EXPANSION	$15,138
														Subtotal = $15,138

Issue Date FY: 2020 ( Subtotal = $146,959 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	000	3	5/12/2020	NON-COMPETING CONTINUATION	$146,959
														Subtotal = $146,959

Issue Date FY: 2019 ( Subtotal = $147,406 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	000	2	5/17/2019	NON-COMPETING CONTINUATION	$147,406
														Subtotal = $147,406

Issue Date FY: 2018 ( Subtotal = $158,600 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Research Related to Deafness and Communication Disorders	000	1	5/30/2018	NEW	$158,600
														Subtotal = $158,600

Grand Total All Awards = $468,103

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Application of graph theory to both resting-state and task-based fMRI data to uncover brain-behavior relationships related to therapy outcomes in aphasia

Award Number: R21DC016708

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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