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An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation

Award Number: R01DA045108
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The proposed research will clarify how heritable risks and prenatal and postnatal environments work together with hormonal changes to influence the development of risk for early substance use (SU) and related problems in adolescence. Understanding the development of SU problems is a vital health concern due to the economic costs of dealing with SU related injury, illness, death, crime, and lost productivity. Pathways and interactions by which genes, prenatal exposures, hormones, and key postnatal environmental factors influence the development of SU are not fully understood, in part because studies have not considered them together. The proposed research is innovative by using and expanding an existing prospective longitudinal adoption study, the Early Growth and Development Study (EGDS) to address the dearth of research combining heritable, prenatal, hormone, and postnatal influences. This proposal is timely, directly addressing PA-15-110, by using genetically informative approaches to expand research on the interplay of genetic and environmental factors in the genesis and course … of substance use disorders and comorbid conditions. The EGDS is a longitudinal study of children adopted at birth and their birth and adoptive parents (N = 561 linked triads). We propose to collect new data into early adolescence on SU milestones and related behaviors, and pubertal development. We will use existing and new data to: (SA1) estimate the unique contributions of heritable risk, prenatal, and postnatal environmental influences on trajectories of child behaviors from infancy to adolescence that increase risk for SU; (SA2) examine the mediating role of prenatal exposures for transmitting heritable influences on trajectories of behavioral risk for SU; (SA3) examine the mediating role of hormone development for transmitting heritable, prenatal and postnatal environmental influences on trajectories of behavioral risk for SU; and (SA4) Examine moderation of heritable, prenatal, and hormone influences by postnatal environments to elucidate the possible interactions among these factors in influencing child risk behaviors and early SU. This study will help to advance knowledge of the development of adolescent SU, to clarify which children are at greater risk for developing SU early in adolescence, and which influences are most salient for SU development given multiple other influences. This prospective, longitudinal, genetically-informed investigation using the EGDS is uniquely poised to achieve these aims, which are critical for gaining a more precise understanding of factors influencing the developmental course of SU that can be used to improve prevention efforts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	000	5	2/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $723,744 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	002	5	3/30/2022	NON-COMPETING CONTINUATION	$66,388
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	001	5	1/20/2022	SUPPLEMENT FOR EXPANSION	$53,870
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	003	5	3/31/2022	SUPPLEMENT FOR EXPANSION	$5,986
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	000	5	1/19/2022	NON-COMPETING CONTINUATION	$597,500
														Subtotal = $723,744

Issue Date FY: 2021 ( Subtotal = $850,680 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	001	4	7/28/2021	SUPPLEMENT FOR EXPANSION	$45,413
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	000	4	2/9/2021	NON-COMPETING CONTINUATION	$805,267
														Subtotal = $850,680

Issue Date FY: 2020 ( Subtotal = $810,572 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	000	3	1/16/2020	NON-COMPETING CONTINUATION	$658,184
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	001	3	7/17/2020	SUPPLEMENT FOR EXPANSION	$152,388
														Subtotal = $810,572

Issue Date FY: 2019 ( Subtotal = $645,889 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	000	2	1/14/2019	NON-COMPETING CONTINUATION	$645,889
														Subtotal = $645,889

Issue Date FY: 2018 ( Subtotal = $702,430 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	000	1	3/16/2018	NEW	$701,755
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Drug Abuse and Addiction Research Programs	001	1	3/29/2018	NEW	$675
														Subtotal = $702,430

Grand Total All Awards = $3,733,315

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An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation

Award Number: R01DA045108

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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