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RNAs that Resist Degradation in the Cell and the Manipulation of RNA Stability in Living Organisms

Award Number: R00GM115757
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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¿ DESCRIPTION (provided by applicant): This proposal describes a research and training plan that is designed to enhance the career development of Dr. Erich G. Chapman. The research aims of this proposal revolve around a series of RNA structures recently discovered within the genomes of different positive-sense RNA viruses. These RNA structures allow portions of these viral genomes to resist or evade the major 5' to 3' and 3' to 5' RNA decay pathways that exist in eukaryotic cells. This leads to a drastic lengthening of the cellular lifetimes of co-transcribed viral RNAs and their high-level accumulation during viral infection. Several lines of evidence suggest that these different RNA stability elements are capable of operating outside of their contexts in different viral genomes. Research described in this proposal will test this hypothesis by transplanting several different viral RNA structures into messenger RNA reporter systems in the model organism S. cerevisiae. Experiments will be conducted to verify their operation and quantify any extensions in cellular RNA lifetimes. These investigations will preface Dr. Chapman's long-term research plans regarding the regulation of RNA metabolism in eukaryotic cells. The career development goals of this proposal are designed to train Dr. Chapman in yeast biology and genomic techniques and to facilitate his transition to an independent academic career. The laboratory skills that Dr. Chapman will develop will build upon his expertise in RNA biochemistry and round out the skill set that he will need as a long-term NIH funded investigator. The training plan that Dr. Chapman will pursue en route to an independent faculty position will include mentoring by Prof. Jeffery S. Kieft, an accomplished HHMI Early Career Scientist and leader in several fields of RNA-related research. Under Dr. Kieft's guidance, Dr. Chapman will engage in a variety of career development activities including mentoring junior scientists, publishing his work in scientific journals, training in the responsible conduct of research, grant-writing, and entry onto the academic job market. Together these activities will enhance Dr. Chapman's skill set and propel him into the successful launch of an independent academic career.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Biomedical Research and Research Training	000	4	12/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $248,938 )
2018	2018	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Biomedical Research and Research Training	000	4	8/30/2018	NON-COMPETING CONTINUATION	$248,938
														Subtotal = $248,938

Issue Date FY: 2017 ( Subtotal = $248,423 )
2017	2017	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Biomedical Research and Research Training	000	3	9/7/2017	NON-COMPETING CONTINUATION	$248,423
														Subtotal = $248,423

Issue Date FY: 2016 ( Subtotal = $248,977 )
2016	2016	UNIVERSITY OF DENVER	UNIVERSITY PARK CAMPUS	DENVER	CO	80210	DENVER	USA	Biomedical Research and Research Training	000	2	9/9/2016	EXTENSION WITH OR WITHOUT FUNDS	$248,977
														Subtotal = $248,977

Grand Total All Awards = $746,338

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RNAs that Resist Degradation in the Cell and the Manipulation of RNA Stability in Living Organisms

Award Number: R00GM115757

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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