The Tribal and Rural Opioid Initiative (TROI) of Utah State University will expand harm reduction education and outreach into six Utah and two New Mexico counties, including the reservation lands of four tribes (Ute, Skull Valley Goshute, Paiute, and the Confederated Tribes of Goshutes). While whole person health is a tenant of harm reduction, many programs focus largely on naloxone trainings, medication treatment, testing services and syringe distribution. In Utah and New Mexico, opioid overdose deaths exceed national averages, and mortality in rural areas from overdose deaths related to opioid and stimulant use exceed urban mortality rates. These mortality rates suggest an immediate need for harm reduction expansion and education, which hinges upon reducing stigma toward harm reduction interventions. TROI will administer a series of training and technical assistance opportunities, focusing on on-demand and real-time offerings that take advantage of online platforms, seeking to better bridge harm reduction and holistic health approaches. Target audiences will range from health professionals working in the area of chronic pain, to community members, to health professionals who may hold stigmatizing beliefs about harm reduction and substance use disorders. Deliverables include a teleconference, podcast, online and in-person book discussion groups, capacity-building webinars, active social media, and an online Master Health Volunteer Program that trains community members on opioid use disorders and the SAMHSA wellness wheel, before readying them to return 40-hours of service to their communities. In-person activities, particularly with tribal partners, will supplement online activities, and include a Tribal Opioid Summit, naloxone and related education, and harm reduction needs assessments with four targeted tribes. All activities will be facilitated through a Community Based Participatory Action framework, centering community members, locally determined priorities and the voices of tribal members and persons in recovery in rural areas. A Holistic Health Coalition will guide a statewide needs assessment and action plan process, while persons in recovery will co-lead community advisory boards for all major activities. Tangible outputs will include two graphic novels that contain stories of the treatment and harm reduction experiences of persons with opioid/stimulant use disorders, because hearing the stories of persons in recovery has been shown to reduce stigma. Book groups will be supported by the SOR provider in New Mexico and Utah Humanities in Utah, leveraging networks to increase the likelihood that people interested in the arts who might not otherwise engage with this content may be drawn to participate. Overall, this program seeks to leverage networks in Utah and New Mexico to increase acceptance of harm reduction best practices, and ultimately reduce overdose mortality in both states. Over 1000 rural residents will be directly served by these grant activities with an estimated additional 10,000 reached through the podcast, social media, graphic novel readership or other indirect channels.