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Environmental Enrichment Promotes Generation of New Oligodendrocytes and Attenuates Hypoxia-Induced Perinatal White Matter Injury

Award Number: F31NS100277
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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PROJECT SUMMARY This application focuses on utilization of environmental enrichment (EE) to attenuate the effects of perinatal hypoxia (HX) on the developing brain. Hypoxic damage to the brain is often sustained as a consequence of preterm birth, and results in cognitive and behavioral disabilities throughout childhood and beyond. This oxygenation failure predisposes preterm infants to white matter (WM) injury, resulting in the loss of oligodendrocyte (OL) glial cells and therefore myelination. One promising non-invasive therapy for promoting recovery after perinatal HX is EE - a combination of social and physical enhancement of surroundings that provides mammals with more complex social interactions, exposure to novel stimuli, and an opportunity for voluntary physical activity. Previous studies have demonstrated that the environment affects neural plasticity and functional recovery after brain injury, and that social, family, and environmental factors can improve cognitive outcome in premature children. This suggests that the environment can be used as a modulator of recovery in premature brain injury, and may enhance the endogenous repair of developing WM after HX insult to restore WM-dependent behavioral function. To test this hypothesis, the effects of EE on cellular, ultrastructural, and functional recovery after HX will be determined using a rodent model of perinatal HX. First, the critical neurodevelopmental window and individual components of EE required for OL recovery after HX will be defined. Then, using genetic manipulations in conditional loss of function mice, the role of EE-induced de novo myelination after HX will be determined. The proposed study utilizes a novel approach to enhance recovery from WM injury in the brain during critical periods of neurodevelopment, and importantly, will aid in the development of new therapeutic strategies to reduce the long-term neurologic sequelae of preterm birth.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$7,122 )
2021	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/12/2021	NON-COMPETING CONTINUATION	-$7,122
														Subtotal = -$7,122

Issue Date FY: 2019 ( Subtotal = -$12,641 )
2019	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/11/2019	NON-COMPETING CONTINUATION	-$13,783
2019	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	3/13/2019	NON-COMPETING CONTINUATION	$1,142
														Subtotal = -$12,641

Issue Date FY: 2018 ( Subtotal = $38,124 )
2018	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/11/2018	NON-COMPETING CONTINUATION	$480
2018	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/8/2017	NON-COMPETING CONTINUATION	$37,644
														Subtotal = $38,124

Issue Date FY: 2017 ( Subtotal = $37,176 )
2017	2017	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	11/7/2016	NEW	$0
2017	2017	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/7/2016	NEW	$37,176
														Subtotal = $37,176

Grand Total All Awards = $55,537

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Environmental Enrichment Promotes Generation of New Oligodendrocytes and Attenuates Hypoxia-Induced Perinatal White Matter Injury

Award Number: F31NS100277

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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